What are the physiological functions of BACE1 beyond APP processing that could cause side effects from therapeutic inhibition?
PARTIALLY ADDRESSED
The abstract identifies BACE1 as an attractive drug target but doesn't address its normal physiological roles. Understanding these functions is critical to predict potential adverse effects of BACE1 inhibitors in therapeutic development.
Gap type: open_question
Source paper: BACE1: the beta-secretase enzyme in Alzheimer's disease. (2004, Journal of molecular neuroscience : MN, PMID:15126696)
Landscape Summary:
What are the physiological functions of BACE1 beyond APP processing that could cause side effects from therapeutic inhibition? is a 0.89 priority gap in neurodegeneration.
It has 0 linked hypotheses with average composite score 0.000.
Status: partially_addressed.
Key Unanswered Questions
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Key Researchers
Colonna, Sevlever, et al. (TREM2 biology)
Clinical Trials
What are the physiological functions of BACE1 beyond APP processing that could cause side effects from therapeutic inhibition? — INVOKE-2 (completed)