| Gene Symbol | NEURODEGENERATION |
| Aliases | neurodegeneration |
| Biogenesis | Endosomal sorting complex required for transport (ESCRT) machinery |
| Intraluminal vesicles | Form within multivesicular bodies (MVBs) |
| Secretion | MVBs fuse with plasma membrane, releasing exosomes |
| Proteins | Surface markers (CD9, CD63, CD81), integrins, signaling molecules |
| Lipids | Cholesterol, sphingolipids, phosphatidylserine |
| RNA | mRNA, miRNA, lncRNA, circular RNA |
| DNA | Genomic DNA, mitochondrial DNA |
| mtDNA copy number | Altered in AD, PD |
| mtDNA mutations | Detectable in disease |
| Circular mtDNA | Emerging biomarker |
| Ultracentrifugation | Gold standard |
| Size-exclusion chromatography | Less harsh |
| Associated Diseases | Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety |
| Known Drugs/Compounds | CANAGLIFLOZIN, Cgmp, DPP-4 INHIBITORS, LITHIUM, MELATONIN, MEMANTINE |
| Interactions | 6-OHDA, ABCA1, ABCD1, ACE, ACE2, ACETYL-COA |
| KG Connections | 6186 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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