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disease 6,462 words KG: FTD
Contents

Frontotemporal Dementia (FTD)

Disease Info
Behavioral variant FTD (bvFTD)Progressive changes in personality, social conduct, and executive function, with early behavioral disinhibition, apathy, loss of empathy, and compulsive/ritualistic behaviors
Associated GenesACHE, AD, AKT, AMYLOID, APOE, APP, BDNF, C9orf72
KG Connections792 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

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🌐 Cross-references

OMIMMeSHWikipedia

Related Hypotheses (41)

Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Stress Granule Phase Separation Modulators
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72Lysosomal Enzyme Trafficking Correction
Score: 0.71Lysosomal Calcium Channel Modulation Therapy
Score: 0.70Mitochondrial Transfer Pathway Enhancement
Score: 0.70Lysosomal Positioning Dynamics Modulation
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65TREM2-mediated microglial tau clearance enhancement
Score: 0.62Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61LRP1-Dependent Tau Uptake Disruption
Score: 0.60VCP-Mediated Autophagy Enhancement
Score: 0.59Extracellular Vesicle Biogenesis Modulation
Score: 0.58Lysosomal Membrane Repair Enhancement
Score: 0.54Blood-Brain Barrier SPM Shuttle System
Score: 0.53Cryptic Exon Silencing Restoration
Score: 0.53Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
← Prevpg 2/3Next →

Related Analyses (13)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD AD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (15)

Frontal and Temporal Lobe Selective Vulnerability in FTD — M
validation · proposed · Score: 0.40C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study
clinical · proposed · Score: 0.40Progranulin Replacement Therapy for FTD — Vector Development
clinical · proposed · Score: 0.40FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40

See Also (15)

GABA (Gamma-Aminobutyric Acid) - Neurodegenerative Dise
biomarker · KG edge: co_discussedFUS (Redirect)
redirect · KG edge: activatesDNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: co_discussedABCD3 Gene
gene · KG edge: activatesACTB Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TAU associated_with FTD
TAU causes FTD
FTD inhibits MITOCHONDRIAL_PROTEINS
FTD inhibits BIOENERGETICS
FTD regulates TAU
TDP43 associated_with FTD
C9ORF72 causes FTD
VESICLE_TRAFFICKING associated_with FTD
GGGGCC_repeat causes FTD
FTD regulates MITOCHONDRIAL_PROTEINS

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