Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DTG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | DTG |
| Key Genes/Proteins | PERK, IRE1 |
| Related Diseases | Blood-Brain Barrier Integrity |
Knowledge base pages for this entity
graph TD
DTG["DTG"]
DTG -->|"activates"| ER_STRESS["ER STRESS"]
DTG -->|"downregulates"| CLDN5["CLDN5"]
DTG -->|"inhibits"| BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"]
DTG -->|"upregulates"| REACTIVE_OXYGEN_SPECIES["REACTIVE OXYGEN SPECIES"]
DTG -->|"upregulates"| HSPA5["HSPA5"]
DTG -->|"upregulates"| IL6["IL6"]
DTG -->|"modulates"| MITOCHONDRIAL_MEMBRANE_POTENTI["MITOCHONDRIAL MEMBRANE POTENTIAL"]
DTG -->|"upregulates"| IL23A["IL23A"]| Target | Relation | Type | Str |
|---|---|---|---|
| ER STRESS | activates | entity | 0.95 |
| CLDN5 | downregulates | entity | 0.95 |
| BLOOD-BRAIN BARRIER | inhibits | entity | 0.95 |
| REACTIVE OXYGEN SPECIES | upregulates | entity | 0.95 |
| Endoplasmic Reticulum Stress | associated_with | process | 0.95 |
| HSPA5 | upregulates | entity | 0.90 |
| IL6 | upregulates | entity | 0.90 |
| MITOCHONDRIAL MEMBRANE POTENTIAL | modulates | entity | 0.90 |
| IL23A | upregulates | entity | 0.90 |
| IL12B | upregulates | entity | 0.90 |
| Blood-Brain Barrier Integrity | associated_with | phenotype | 0.90 |
| PERK | activates | protein | 0.90 |
| IRE1 | activates | protein | 0.90 |
| Reactive Oxygen Species | upregulates | process | 0.90 |
| reactive oxygen species production | promotes | process | 0.88 |
| NEUROPSYCHIATRIC ADVERSE EFFECT | causes | entity | 0.85 |
| EIF2A | upregulates | protein | 0.85 |
| ATF4 | upregulates | protein | 0.85 |
| DDIT3 | upregulates | protein | 0.85 |
| XBP1 | upregulates | protein | 0.85 |
| TJP1 | downregulates | protein | 0.85 |
| OCLN | downregulates | protein | 0.85 |
| calcium flux | modulates | process | 0.85 |
| CXCL1 | upregulates | protein | 0.85 |
| ER_stress | associated_with | biological_process | 0.80 |
| Neuropsychiatric Adverse Effect | risk_factor_for | phenotype | 0.80 |
| neuropsychiatric adverse effects | associated_with | phenotype | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||