IL23A

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL23A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Interleukin 23 Subunit Alpha gene encoding IL-23p19, a key cytokine subunit involved in Th17 cell differentiation and neuroinflammation in neurodegenerative diseases

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graph TD
    IL23A["<b>IL23A</b>"]
    Ms{"Ms"}
    IL23A -->|"therapeutic target"| Ms
    Als{"Als"}
    IL23A -->|"therapeutic target"| Als
    IL23A -->|"activates"| Als
    IL23A -->|"interacts with"| Ms
    ALS{"ALS"}
    IL23A -->|"activates"| ALS
    Er_Stress(["Er Stress"])
    IL23A -->|"inhibits"| Er_Stress
    Blood_Brain_Barrier(["Blood-Brain Barrier"])
    IL23A -->|"therapeutic target"| Blood_Brain_Barrier
    OCLN["OCLN"]
    IL23A -->|"inhibits"| OCLN
    CXCL1["CXCL1"]
    IL23A -->|"inhibits"| CXCL1
    CXCL2["CXCL2"]
    IL23A -->|"inhibits"| CXCL2
    PPP1R15A["PPP1R15A"]
    IL23A -->|"therapeutic target"| PPP1R15A
    XBP1["XBP1"]
    IL23A -->|"therapeutic target"| XBP1
    STAT3["STAT3"]
    STAT3 -->|"regulates"| IL23A
    STAT3 -->|"activates"| IL23A
    CXCL2 -->|"inhibits"| IL23A
    IL6["IL6"]
    IL6 -->|"inhibits"| IL23A
    ATF4["ATF4"]
    ATF4 -->|"therapeutic target"| IL23A
    PPP1R15A -->|"therapeutic target"| IL23A
    IL12B["IL12B"]
    IL12B -->|"inhibits"| IL23A
    XBP1 -->|"therapeutic target"| IL23A
    CXCL1 -->|"inhibits"| IL23A
    DDIT3["DDIT3"]
    DDIT3 -->|"therapeutic target"| IL23A
    CLDN5["CLDN5"]
    CLDN5 -->|"inhibits"| IL23A
    HSPA5["HSPA5"]
    HSPA5 -->|"therapeutic target"| IL23A
    style IL23A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0