IL12B

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL12B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

IL12B is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, inhibits. Associated with ALS, Als, Atherosclerosis. Connected to 53 entities in the SciDEX knowledge graph.

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graph TD
    IL12B["<b>IL12B</b>"]
    primary_Sjogren_disease{"primary_Sjogren_disease"}
    IL12B -->|"decreases risk"| primary_Sjogren_disease
    Ms{"Ms"}
    IL12B -->|"therapeutic target"| Ms
    Als{"Als"}
    IL12B -->|"therapeutic target"| Als
    IL12B -->|"activates"| Als
    Atherosclerosis{"Atherosclerosis"}
    IL12B -->|"expressed in"| Atherosclerosis
    IL12B -->|"expressed in"| Ms
    Tumor{"Tumor"}
    IL12B -->|"expressed in"| Tumor
    ALS{"ALS"}
    IL12B -->|"activates"| ALS
    XBP1["XBP1"]
    IL12B -->|"therapeutic target"| XBP1
    CXCL1["CXCL1"]
    IL12B -->|"inhibits"| CXCL1
    DDIT3["DDIT3"]
    IL12B -->|"therapeutic target"| DDIT3
    CLDN5["CLDN5"]
    IL12B -->|"inhibits"| CLDN5
    CXCL2["CXCL2"]
    CXCL2 -->|"inhibits"| IL12B
    IL6["IL6"]
    IL6 -->|"inhibits"| IL12B
    ATF4["ATF4"]
    ATF4 -->|"therapeutic target"| IL12B
    PPP1R15A["PPP1R15A"]
    PPP1R15A -->|"therapeutic target"| IL12B
    ATF4 -->|"activates"| IL12B
    CLDN5 -->|"inhibits"| IL12B
    DMSO["DMSO"]
    DMSO -->|"expressed in"| IL12B
    TNF["TNF"]
    TNF -->|"activates"| IL12B
    ZFP36L2["ZFP36L2"]
    ZFP36L2 -->|"expressed in"| IL12B
    ZFP36["ZFP36"]
    ZFP36 -->|"expressed in"| IL12B
    XBP1 -->|"activates"| IL12B
    HSPA5["HSPA5"]
    HSPA5 -->|"activates"| IL12B
    style IL12B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0