concept

REACTIVE OXYGEN SPECIES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REACTIVE OXYGEN SPECIES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

518Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	REACTIVE OXYGEN SPECIES
Summary	# [Reactive Oxygen Species](/entities/reactive-oxygen-species) ([ROS](/entities/reactive-oxygen-species)) ## Introduction [Reactive Oxygen Species](/entities/reactive-oxygen-species) (Ros) is an impo
Key Genes/Proteins	RTN3, SESN2, SNCA, SNCAIP, SQSTM1, P62
Related Diseases	ALS

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    REACTIVE_OXYGEN_SPECIES["REACTIVE OXYGEN SPECIES"]
    REACTIVE_OXYGEN_SPECIES -->|"modulates"| DUBS["DUBS"]
    REACTIVE_OXYGEN_SPECIES -->|"modulates"| DUB["DUB"]
    REACTIVE_OXYGEN_SPECIES -->|"involved_in"| Neutrophil_Extracellular_Traps["Neutrophil Extracellular Traps"]
    REACTIVE_OXYGEN_SPECIES -.biomarker for.-> Hypertrophic_Scar["Hypertrophic Scar"]
    REACTIVE_OXYGEN_SPECIES -->|"modulates"| Catalytic_Cysteine["Catalytic Cysteine"]
    REACTIVE_OXYGEN_SPECIES -->|"contributes to"| amyloid_beta["amyloid beta"]
    REACTIVE_OXYGEN_SPECIES -->|"activates"| Separating_Microneedles["Separating Microneedles"]
    REACTIVE_OXYGEN_SPECIES -->|"contributes to"| Learning_and_Memory_Deficits["Learning and Memory Deficits"]
    REACTIVE_OXYGEN_SPECIES -->|"contributes to"| Protein_Accumulation["Protein Accumulation"]
    REACTIVE_OXYGEN_SPECIES -->|"activates"| mitochondrial_dysfunction["mitochondrial dysfunction"]
    HSPA1A["HSPA1A"] -->|"inhibits"| REACTIVE_OXYGEN_SPECIES
    Antioxidants["Antioxidants"] -->|"downregulates"| REACTIVE_OXYGEN_SPECIES
    PGC1A["PGC1A"] -->|"regulates"| REACTIVE_OXYGEN_SPECIES
    SLC7A11["SLC7A11"] -->|"downregulates"| REACTIVE_OXYGEN_SPECIES
    MT1["MT1"] -->|"modulates"| REACTIVE_OXYGEN_SPECIES
    MT2["MT2"] -->|"modulates"| REACTIVE_OXYGEN_SPECIES
    Dolutegravir["Dolutegravir"] -->|"upregulates"| REACTIVE_OXYGEN_SPECIES
    Lactic_Acid["Lactic Acid"] -->|"downregulates"| REACTIVE_OXYGEN_SPECIES
    GJA1_20k["GJA1-20k"] -->|"downregulates"| REACTIVE_OXYGEN_SPECIES
    Mitophagic_Flux_Inhibition["Mitophagic Flux Inhibition"] -->|"causes"| REACTIVE_OXYGEN_SPECIES

Outgoing (71)

Target	Relation	Type	Str
Alzheimer's Disease	contributes_to	disease	0.95
Neurodegeneration	causes	process	0.95
Parkinson Disease	contributes_to	disease	0.95
PANoptosis	activates	process	0.90
Acute Kidney Injury	associated_with	disease	0.90
Neurodegeneration	contributes_to	process	0.90
AMPK-mTOR Pathway	activates	pathway	0.90
DNM1L	phosphorylates	protein	0.90
GSDME	cleaves	protein	0.88
Oxidative Stress	causes	process	0.88
ZBP1	activates	protein	0.85
chondrocytes	associated_with	cell_type	0.85
cytoskeletal proteins	degrades	protein	0.85
Amyloid Beta Aggregation	upregulates	process	0.85
Mitochondrial Impairment	causes	phenotype	0.85
TFEB Nuclear Translocation	mediates	mechanism	0.85
Hypertrophic Scar	drives	disease	0.85
glioblastoma	treats	disease	0.85
amyloid beta	contributes_to	protein	0.80
proinflammatory cytokines	increases	compound	0.80
cognitive deficits	causes	phenotype	0.80
Diabetes-Associated Cognitive Impairment	contributes_to	disease	0.80
Senescence	contributes_to	process	0.80
P53	upstream_of	gene	0.80
Stimuli-responsive nanoplatforms	associated_with	compound	0.75
oxidative damage	activates	process	0.70
neuronal damage	activates	process	0.70
Mitochondrial dysfunction	activates	process	0.70
Oxidative stress	activates	process	0.70
BBB disruption	activates	process	0.70
neuroapoptosis	activates	process	0.70
brain damage	causes	process	0.70
Oxidative stress	causes	process	0.70
Brain cell death	activates	process	0.70
mitochondrial fragmentation	activates	process	0.70
mitochondrial dysfunction	activates	process	0.70
oxidative stress	activates	process	0.70
NUCLEUS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
PEROXISOME	activates	concept	0.50
Proteins	activates	protein	0.50
MONOCYTES	interacts_with	concept	0.50
HEPATOCYTES	interacts_with	concept	0.50
DENDRITIC CELLS	interacts_with	concept	0.50
Cellular Senescence	activates	cell_type	0.50
α-SYNUCLEIN	causes	concept	0.50
AUTOPHAGOSOME	activates	concept	0.50
Proteins	causes	protein	0.50
WNT SIGNALING	inhibits	concept	0.50

Incoming (447)

Source	Relation	Type	Str
DTG	upregulates	entity	0.95
Ferroptosis	causes	process	0.95
Celastrol	promotes	compound	0.95
TRPML1-TFEB pathway	inhibits	pathway	0.93
Type I photodynamic therapy	associated_with	process	0.92
curcumin	inhibits	drug	0.90
HSPA1A	suppresses	gene	0.90
GJA1-20k	suppresses	protein	0.90
selenium-containing compound	associated_with	compound	0.90
stroke	causes	disease	0.90
Mitochondrial Dysfunction	causes	process	0.90
PPARGC1A	regulates	gene	0.90
DTG	upregulates	drug	0.90
FOXO1	regulates	gene	0.90
Rg1	associated_with	compound	0.90
Icariin	inhibits	compound	0.90
Crocetin	suppresses	compound	0.90
Dolutegravir	upregulates	drug	0.88
SLC15A3	regulates	protein	0.85
PPARGC1A	modulates	gene	0.85
Quercetier	downregulates	compound	0.85
2,2,6,6-tetramethylpiperidine-1-oxyl	associated_with	compound	0.85
Paeoniflorin	modulates	compound	0.85
Photodynamic Therapy	mediates	process	0.85
CREBBP	regulates	gene	0.85
AKT	modulates	protein	0.85
ischemia-reperfusion injury	increases	disease	0.80
APOE	increases	gene	0.80
SIRT3	regulates	gene	0.80
Egcg	modulates	compound	0.80
AMYLOID-BETA	associated_with	protein	0.80
PRKAA1	regulates	gene	0.80
Tryptamine	associated_with	compound	0.80
5-fluorouracil	suppresses	drug	0.80
MICROGLIA	releases	cell_type	0.80
ERK	inhibits	protein	0.75
autophagy	regulates	process	0.70
lipid droplet formation	activates	process	0.70
Tau protein	activates	protein	0.70
Amyloid β	activates	protein	0.70
intraocular pressure	activates	process	0.70
ethanol	activates	drug	0.70
melatonin	inhibits	drug	0.70
Ischemic stroke	associated_with	disease	0.70
Ischemia/reperfusion injury	activates	process	0.70
amyloid beta	activates	protein	0.70
hyperphosphorylated tau	activates	protein	0.70
Ginsenoside Rb1	inhibits	drug	0.70
mitochondrial dysfunction	activates	process	0.70
HSPA1A	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

REACTIVE OXYGEN SPECIES

Understanding Entity Pages

Wiki Pages (21)