| Gene Symbol | FYCO1 |
| Full Name | FYVE and Coiled-Coil Domain Containing 1 |
| Chromosome | 3p21.2 |
| Function | FYCO1 encodes a autophagy adapter protein that links autophagosomes to the microtubule-based transport machinery. |
| Primary Expression | the lens, and mutations cause congenital cataract, often accompanying spastic paraplegia in SPG59 |
| Pathways | mTOR, mtor |
| UniProt ID | Q9BQR1 |
| NCBI Gene ID | 79443 |
| Ensembl ID | ENSG00000164120 |
| OMIM | 607781 |
| GeneCards | FYCO1 |
| Human Protein Atlas | FYCO1 |
| FYVE domain | binds to phosphatidylinositol 3-phosphate (PI3P) on autophagosomal membranes |
| Coiled-coil domains | mediate protein-protein interactions |
| LC3-interacting region (LIR) | binds LC3/GABARAP proteins |
| Associated Diseases | Cancer, Cardiovascular, Ischemia, Ms, Neurodegeneration, Parkinson |
| Known Drugs/Compounds | rapamycin |
| Interactions | AMPK, AMYLOID, AND, APOPTOSIS, AR, ATG |
| KG Connections | 169 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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