gene 666 words KG: DHCR24 2026-03-22
kind:genesection:genesstate:published
Contents

DHCR24 Gene

🧬 Gene Info
Gene SymbolDHCR24
Full Name24-Dehydrocholesterol Reductase
Chromosome1p31.3
Protein FamilyFAD-dependent oxidoreductases
Protein TypeEnzyme
Functionencodes an enzyme involved in the final step of cholesterol biosynthesis, converting 24-dehydrocholesterol to cholesterol.
Primary Expressionthe brain and essential for neuronal survival
Subcellular LocalizationEndoplasmic reticulum, lipid rafts
Molecular Weight~56 kDa (489 amino acids)
Amino Acids489 aa
PathwaysViral Uptake, epigenetic regulation, unfolded protein response
UniProt IDQ8N0Y2
NCBI Gene ID1719
Ensembl IDENSG00000116133
OMIM606417
GeneCardsDHCR24
Human Protein AtlasDHCR24
Associated DiseasesAD, AMI, Als, Alzheimer, Alzheimer's disease, RA
Known Drugs/Compoundsrapamycin
InteractionsMAPT, PARP1, PEN2, PSEN1, DAPK1, HSPG2
KG Connections120 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
PARP1 Inhibition Therapy
Score: 0.58
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived

See Also (13)

Packard Center for ALS Research
institution · KG edge: implicated_in
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: interacts_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with

Knowledge Graph (12 edges)

DHCR24 associated_with ALZHEIMER'S DISEASE
DHCR24 associated_with HMGCR
DHCR24 interacts_with MAPT
DHCR24 interacts_with PARP1
DHCR24 interacts_with PEN2
DHCR24 interacts_with PSEN1
DHCR24 interacts_with DAPK1
DHCR24 interacts_with HSPG2
DHCR24 interacts_with IL1B
DHCR24 interacts_with APP