gene 579 words KG: BCL2L11 2026-03-21
kind:genesection:genesstate:published
Contents

BCL2L11 Gene

🧬 Gene Info
Gene SymbolBCL2L11
Full NameBCL2 Like 11 (BIM)
Chromosome2q13
Functionis a potent pro-apoptotic BH3-only protein that belongs to the Bcl-2 family.
Primary ExpressionUbiquitous; high expression in neuronal tissues
PathwaysMAPK signaling, Reactive Oxygen Species, apoptosis, apoptosis pathway, autophagy pathway
UniProt IDO43521
NCBI Gene ID10018
Ensembl IDENSG00000113194
OMIM603677
GeneCardsBCL2L11
Human Protein AtlasBCL2L11
Associated DiseasesAD, ALI, ALS, Alzheimer, Parkinson
InteractionsMUL1, BNIP3, DISC1, EIF2S1, RIPK3, DRP1
KG Connections466 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49

Related Analyses (5)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (11)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: interacts_with
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: implicated_in
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: interacts_with

Knowledge Graph (12 edges)

BCL2L11 interacts_with MUL1
BCL2L11 interacts_with BNIP3
BCL2L11 interacts_with DISC1
BCL2L11 interacts_with EIF2S1
BCL2L11 interacts_with RIPK3
BCL2L11 interacts_with DRP1
BCL2L11 interacts_with CHOP
BCL2L11 interacts_with BECN1
BCL2L11 interacts_with PTEN
BCL2L11 interacts_with DDIT3