| Gene Symbol | CASP1 |
| Chromosome | 11q22.3 |
| Protein Type | Protease |
| Target Class | Protease |
| Function | Small molecule covalent inhibitor of caspase-1 proteolytic activity |
| Mechanism of Action | Small molecule covalent inhibitor of caspase-1 proteolytic activity |
| Druggability | Medium (0.46) |
| Clinical Stage | Phase II |
| Molecular Weight | 45 kDa |
| Amino Acids | 404 aa |
| Exons | 11 |
| Pathways | NF-κB |
| UniProt ID | A0A8Q3SI00 |
| NCBI Gene ID | 842 |
| GeneCards | CASP1 |
| Human Protein Atlas | CASP1 |
| Associated Diseases | Aging, Als, ALZHEIMER, atherosclerosis |
| Known Drugs/Compounds | KAEMPFEROL, Pterostilbene, rapamycin |
| Interactions | ACTB, AGING, AIF1, AIM2, AKT3, ALZHEIMER |
| SciDEX Target | View Target Profile (3 clinical trials) |
| KG Connections | 848 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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