| Gene Symbol | CTSD |
| Full Name | Cathepsin D |
| Aliases | CPSD, CLN10 |
| Chromosome | 11p15.5 |
| Protein Type | Protease |
| Function | is a lysosomal aspartic protease encoded by the CTSD gene. |
| Primary Expression | Brain, liver, macrophages, neurons, microglia |
| Molecular Weight | 48 kDa |
| Pathways | Akt, Angiogenesis, Apoptosis, Autophagy, Blood-Brain Barrier |
| UniProt ID | P07339 |
| NCBI Gene ID | 1509 |
| Ensembl ID | ENSG00000103811 |
| GeneCards | CTSD |
| Human Protein Atlas | CTSD |
| N-terminal lobe | Contains the activation peptide (propeptide, ~44 amino acids) that blocks the active site; cleavage of this peptide is required for activation |
| Associated Diseases | AD, ADH, Aging, ALI, Als |
| Known Drugs/Compounds | CHLOROQUINE, COENZYME Q10, H2S, rapamycin, RAPAMYCIN |
| Interactions | ABCA1, ABCD3, ACTB, Actin, ADRA2A, AGING |
| SciDEX Hypotheses | Cathepsin D Enhancement for Tau Degradation |
| KG Connections | 1554 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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