Contents

EFNB1 Gene

🧬 Gene Info

Gene Symbol	EFNB1
Protein Type	Receptor
Function	is a transmembrane ligand for EPHB receptors that mediates cell-cell communication and regulates synaptic plasticity, neural development, and cellular signaling.
Primary Expression	both embryonic and adult tissues: - Brain: High expression in hippocampus, cortex, [olfacto
Molecular Weight	38 kDa
Amino Acids	346 aa
Pathways	Apoptosis, Cell Proliferation, PI3K-AKT-mTOR signaling, Pi3K, senescence
Ensembl ID	ENSG00000190784
GeneCards	EFNB1
Human Protein Atlas	EFNB1
N-terminal receptor-binding domain	The extracellular domain that binds EPHB receptors with high affinity
cysteine-rich region	Contains conserved cysteine residues that form disulfide bonds
Transmembrane helix	A single pass transmembrane domain that anchors the protein in the membrane
C-terminal cytoplasmic domain	Contains PDZ-binding motifs that interact with intracellular signaling proteins
Forward signaling	EFNB1 binding activates EPHB receptor tyrosine kinase signaling in the receptor-expressing cell
Associated Diseases	AD, ALI, cancer, carcinoma, ESCC
Known Drugs/Compounds	quercetin
Interactions	AGING, AKT, AND, APOPTOSIS, BCL-XL, EPHB4
KG Connections	95 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph