biological_process

ANGIOGENESIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANGIOGENESIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1187Connections

0Hypotheses

0Analyses

50Outgoing

29Incoming

No summary available yet. View on Wiki →

🧬 Biological Process Info

Name	ANGIOGENESIS
Summary	Page for Angiogenesis Pathway
Key Genes/Proteins	SMPD1, BMAL1, FGF2, ERK, EGF, AKT
Related Diseases	SENESCENCE, GLYCOLYSIS, ASTHMA, ALZHEIMER'S DISEASE

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ANGIOGENESIS["ANGIOGENESIS"] -->|"associated"| CANCER["CANCER"]
    style CANCER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"targets"| STING["STING"]
    style STING fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"activates"| TUMOR["TUMOR"]
    style TUMOR fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"accumulates in"| CELL_MIGRATION["CELL MIGRATION"]
    style CELL_MIGRATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"accumulates in"| INFLAMMATION["INFLAMMATION"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"regulates"| APOPTOSIS["APOPTOSIS"]
    style APOPTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"targets"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    NTN1["NTN1"] -->|"associated"| ANGIOGENESIS["ANGIOGENESIS"]
    style NTN1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    BMAL1["BMAL1"] -->|"regulates"| ANGIOGENESIS["ANGIOGENESIS"]
    style BMAL1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AKT["AKT"] -->|"co discussed"| ANGIOGENESIS["ANGIOGENESIS"]
    style AKT fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    CYTOKINES["CYTOKINES"] -->|"associated"| ANGIOGENESIS["ANGIOGENESIS"]
    style CYTOKINES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    STING_1["STING"] -->|"activates"| ANGIOGENESIS["ANGIOGENESIS"]
    style STING_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style ANGIOGENESIS fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (167)

Target	Relation	Type	Str
ENDOTHELIAL CELLS	regulates	cell_type	0.80
ENDOTHELIAL CELLS	associated_with	cell_type	0.65
EGF	inhibits	gene	0.60
AKT	activates	gene	0.58
ALZHEIMER'S DISEASE	depleted_in	disease	0.55
AXON	co_discussed	entity	0.50
ENDOTHELIAL	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
SENESCENCE	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
CIRCADIAN	co_discussed	entity	0.50
MACROPHAGE	co_discussed	entity	0.50
AUTOPHAGY	co_discussed	entity	0.50
MACROPHAGES	co_discussed	entity	0.50
APOPTOSIS	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
NEURON	co_discussed	entity	0.50
MTOR	co_discussed	entity	0.50
MACROPHAGES	activates	cell_type	0.50
METASTASIS	implicated_in	process	0.50
ENDOTHELIAL CELLS	activates	cell_type	0.50
MOTOR CORTEX	associated_with	brain_region	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
CEREBELLUM	associated_with	brain_region	0.50
STRIATUM	associated_with	brain_region	0.50
CORTEX	associated_with	brain_region	0.50
LUTEOLIN	associated_with	drug	0.50
RAPAMYCIN	associated_with	drug	0.45
BEVACIZUMAB	associated_with	drug	0.45
SPINAL CORD	associated_with	brain_region	0.45
PI3K	activates	gene	0.44
ENDOTHELIAL CELLS	co_discussed	cell_type	0.40
FGF2	co_discussed	gene	0.40
CELL PROLIFERATION	co_discussed	process	0.40
METASTASIS	co_discussed	process	0.40
BREAST CANCER	co_discussed	disease	0.40
OXIDATIVE STRESS	co_discussed	process	0.40
MICROGLIA	co_discussed	cell_type	0.40
ASTROCYTE	co_discussed	cell_type	0.40
NEUROINFLAMMATION	co_discussed	process	0.40
STROKE	co_discussed	disease	0.40
VEGF	co_discussed	gene	0.40
ISCHEMIA	co_discussed	disease	0.40
UBIQUITIN	co_discussed	protein	0.40
PERICYTE	co_discussed	cell_type	0.40
T CELLS	co_discussed	cell_type	0.40
NEURONS	co_discussed	cell_type	0.40
CELL PROLIFERATION	implicated_in	process	0.35
CELL CYCLE	associated_with	process	0.35
NEUROGENESIS	activates	process	0.35

Incoming (1020)

Source	Relation	Type	Str
SMPD1	inhibits	gene	0.90
NTN1	associated_with	entity	0.85
non-coding RNAs	regulates	molecule	0.80
BMAL1	regulates	gene	0.72
FGF2	interacts_with	gene	0.65
SENESCENCE	inhibits	phenotype	0.65
GLYCOLYSIS	activates	phenotype	0.65
ERK	inhibits	gene	0.65
ASTHMA	causes	disease	0.65
ENDOTHELIAL CELLS	participates_in	cell_type	0.55
FGF2	implicated_in	gene	0.55
MACROPHAGE	depleted_in	cell_type	0.55
UBIQUITIN	expressed_in	protein	0.55
NGF	implicated_in	gene	0.55
AKT	co_discussed	entity	0.50
DENTATE GYRUS	associated_with	brain_region	0.50
PI3K/AKT PATHWAY	associated_with	pathway	0.45
NEURONS	associated_with	cell_type	0.45
ALZHEIMER	co_discussed	disease	0.40
ALZHEIMER'S DISEASE	co_discussed	disease	0.40
AKT	phosphorylates	gene	0.35
CYTOKINES	associated_with	protein	0.30
STING	activates	gene	0.30
STING	implicated_in	gene	0.30
DEPRESSION	activates	disease	0.30
IMMUNE RESPONSE	associated_with	process	0.30
NEUROINFLAMMATION	associated_with	process	0.30
OXIDATIVE STRESS	associated_with	process	0.30
ATHEROSCLEROSIS	implicated_in	disease	0.30

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ANGIOGENESIS

Understanding Entity Pages

Wiki Pages (21)

Angiogenesis Pathway

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Therapeutics

neuroinflammation

CBS/PSP Treatment Rankings

TREM2 Mechanism Hub

Growth Factor Therapies

APOC4 — Apolipoprotein C-IV

amyloid-beta-metalloproteinases

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

VEGF/Angiogenesis Pathway in Neurodegeneration

Growth Factor Therapeutics: Investment Landscape Analysis

IGF-1 Signaling Pathway in Neurodegeneration

Astrocytes

Microglial Senescence Pathway in Neurodegeneration

neurovascular-coupling

Notch Signaling Pathway in Neurodegeneration