biological_process

ANGIOGENESIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANGIOGENESIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1197Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

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🧬 Biological Process Info

Name	ANGIOGENESIS
Key Genes/Proteins	AKT, AMYLOID
Related Diseases	ALZHEIMER, ALZHEIMER'S DISEASE, ASTHMA

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Angiogenesis Pathway

mechanism · 1518 words

→

Pathway Diagram

graph TD
    ANGIOGENESIS["ANGIOGENESIS"] -->|"associated"| CANCER["CANCER"]
    style CANCER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"targets"| STING["STING"]
    style STING fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"activates"| TUMOR["TUMOR"]
    style TUMOR fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"accumulates in"| CELL_MIGRATION["CELL MIGRATION"]
    style CELL_MIGRATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"accumulates in"| INFLAMMATION["INFLAMMATION"]
    style INFLAMMATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"regulates"| APOPTOSIS["APOPTOSIS"]
    style APOPTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    ANGIOGENESIS["ANGIOGENESIS"] -->|"targets"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    style OXIDATIVE_STRESS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    NTN1["NTN1"] -->|"associated"| ANGIOGENESIS["ANGIOGENESIS"]
    style NTN1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    BMAL1["BMAL1"] -->|"regulates"| ANGIOGENESIS["ANGIOGENESIS"]
    style BMAL1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AKT["AKT"] -->|"co discussed"| ANGIOGENESIS["ANGIOGENESIS"]
    style AKT fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    CYTOKINES["CYTOKINES"] -->|"associated"| ANGIOGENESIS["ANGIOGENESIS"]
    style CYTOKINES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    STING_1["STING"] -->|"activates"| ANGIOGENESIS["ANGIOGENESIS"]
    style STING_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style ANGIOGENESIS fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (220)

Target	Relation	Type	Str
Wound Healing	involved_in	process	0.95
Wound Healing	contributes_to	process	0.95
Bone Fracture Healing	involved_in	process	0.95
Brain Development	involved_in	process	0.95
Brain Vascular Malformations	associated_with	disease	0.90
Brain Tumors	associated_with	disease	0.90
Fracture Healing	contributes_to	process	0.90
ENDOTHELIAL CELLS	regulates	cell_type	0.80
VEGF	interacts_with	entity	0.70
ENDOTHELIAL CELLS	associated_with	cell_type	0.65
MMP9	inhibits	gene	0.60
MMP2	inhibits	gene	0.60
oxidative stress	activates	process	0.60
CLOCK	regulates	gene	0.60
CLOCK	binds_to	gene	0.60
SRPK1	phosphorylates	gene	0.60
CX3CR1	activates	gene	0.60
NPM1	activates	gene	0.60
AQP1	activates	gene	0.60
apoptosis	associated_with	pathway	0.60
neuroinflammation	binds_to	process	0.60
AQP1	regulates	gene	0.60
EGF	inhibits	gene	0.60
PIEZO1	activates	gene	0.60
AKT	activates	gene	0.58
Mtor	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Notch	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Immune Response	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Adaptive Immunity	interacts_with	pathway	0.55
Pi3K	interacts_with	pathway	0.55
Epigenetic	interacts_with	pathway	0.55
ALZHEIMER'S DISEASE	depleted_in	disease	0.55
Glycolysis	interacts_with	pathway	0.55
AXON	co_discussed	entity	0.50
NEURON	co_discussed	cell_type	0.50
MACROPHAGES	activates	cell_type	0.50
MTOR	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
APOPTOSIS	co_discussed	entity	0.50
METASTASIS	implicated_in	process	0.50
MACROPHAGES	co_discussed	entity	0.50
AUTOPHAGY	co_discussed	entity	0.50
MACROPHAGE	co_discussed	entity	0.50
CIRCADIAN	co_discussed	entity	0.50
ENDOTHELIAL CELLS	activates	cell_type	0.50
MITOCHONDRIA	co_discussed	entity	0.50
SENESCENCE	co_discussed	entity	0.50

Incoming (977)

Source	Relation	Type	Str
CANCER	inhibits	gene	1.00
Cancer	inhibits	disease	1.00
OXIDATIVE STRESS	activates	gene	1.00
Ischemia	activates	disease	1.00
Cancer	regulates	disease	1.00
INFLAMMATION	inhibits	gene	1.00
INFLAMMATION	activates	gene	1.00
MTOR	therapeutic_target	gene	1.00
Inflammation	activates	disease	1.00
Inflammation	therapeutic_target	disease	1.00
AKT	therapeutic_target	gene	1.00
AKT	activates	gene	1.00
PI3K	therapeutic_target	gene	1.00
GENES	activates	gene	1.00
Tumor	inhibits	disease	1.00
STAT3	activates	gene	1.00
Als	activates	disease	1.00
Als	therapeutic_target	disease	1.00
Tumor	activates	disease	1.00
Cancer	activates	disease	1.00
APOPTOSIS	regulates	gene	1.00
APOPTOSIS	inhibits	gene	1.00
Tumor	regulates	disease	1.00
AKT	regulates	gene	1.00
Tumor	therapeutic_target	disease	1.00
CANCER	activates	gene	1.00
PI3K	regulates	gene	1.00
CANCER	therapeutic_target	gene	1.00
PI3K	activates	gene	1.00
CANCER	regulates	gene	1.00
GENES	regulates	gene	1.00
Als	inhibits	disease	1.00
APOPTOSIS	activates	gene	1.00
Cancer	therapeutic_target	disease	1.00
Inflammation	inhibits	disease	1.00
Als	regulates	disease	1.00
AUTOPHAGY	regulates	gene	1.00
VEGF	activates	gene	1.00
MTOR	regulates	gene	1.00
MICRORNAS	regulates	gene	1.00
AKT	inhibits	gene	1.00
PI3K	inhibits	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
CYTOKINES	therapeutic_target	gene	1.00
Inflammation	regulates	disease	1.00
TNF	activates	gene	1.00
CYTOKINES	activates	gene	1.00
TNF-Α	activates	gene	1.00
BMAL1	regulates	gene	0.95
Notch Signaling Pathway	associated_with	pathway	0.95