concept

SULFORAPHANE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SULFORAPHANE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

76Connections

0Hypotheses

0Analyses

46Outgoing

16Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	SULFORAPHANE
Key Genes/Proteins	BDNF, HDAC2, TAU, AQP4
Related Diseases	OXIDATIVE STRESS, ISCHEMIA

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SULFORAPHANE["SULFORAPHANE"]
    SULFORAPHANE -->|"activates"| TFEB["TFEB"]
    SULFORAPHANE -->|"activates"| lipophagy["lipophagy"]
    SULFORAPHANE -->|"activates"| AMPK["AMPK"]
    SULFORAPHANE -->|"mediates"| TFEB_Nuclear_Translocation["TFEB Nuclear Translocation"]
    SULFORAPHANE -->|"treats"| Oxidative_Stress["Oxidative Stress"]
    SULFORAPHANE -->|"contributes to"| LC3["LC3"]
    SULFORAPHANE -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    SULFORAPHANE -->|"suppresses"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]

Outgoing (60)

Target	Relation	Type	Str
ASTROCYTES	protects_against	cell_type	0.70
ASTROCYTES	activates	cell_type	0.70
BDNF	activates	gene	0.65
HDAC2	inhibits	gene	0.65
BDNF	modifies	gene	0.65
BDNF	regulates	gene	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
TAU	inhibits	protein	0.65
AQP4	regulates	gene	0.65
AQP4	protects_against	gene	0.65
ISCHEMIA	activates	disease	0.65
BDNF	phosphorylates	gene	0.65
BDNF	expressed_in	gene	0.55
ASTROCYTES	associated_with	cell_type	0.50
ASTROCYTE	associated_with	cell_type	0.50
NRF2	associated_with	gene	0.50
MAPK	associated_with	gene	0.50
AUTOPHAGY	associated_with	phenotype	0.50
KEAP1	associated_with	gene	0.50
HMOX1	associated_with	gene	0.50
LAMP1	associated_with	gene	0.50
MTOR	associated_with	gene	0.50
TFEB	associated_with	gene	0.50
HO-1	associated_with	gene	0.50
ROS	associated_with	phenotype	0.50
RESVERATROL	associated_with	drug	0.45
CURCUMIN	associated_with	drug	0.45
TREM2	associated_with	gene	0.45
SIRT1	associated_with	gene	0.45
TGFB1	associated_with	gene	0.45
HMGB1	associated_with	gene	0.45
STING	associated_with	gene	0.45
BDNF	associated_with	gene	0.45
ALZHEIMER	associated_with	disease	0.45
NEURONS	associated_with	cell_type	0.45
CREB	associated_with	gene	0.45
AKT	associated_with	gene	0.45
ERK	associated_with	gene	0.45
HDAC2	associated_with	gene	0.45
RAPAMYCIN	associated_with	drug	0.45
QUERCETIN	associated_with	drug	0.45
DASATINIB	associated_with	drug	0.45
TAU	associated_with	protein	0.45
CHOLESTEROL	associated_with	phenotype	0.45
AQP4	associated_with	gene	0.45
ISCHEMIA	associated_with	disease	0.45

Incoming (16)

Source	Relation	Type	Str
OXIDATIVE STRESS	associated_with	phenotype	0.50
ATHEROSCLEROSIS	associated_with	disease	0.50
ALZHEIMER'S DISEASE	associated_with	disease	0.45
CURCUMIN	associated_with	drug	0.45
HMGB1	associated_with	gene	0.45
RESVERATROL	associated_with	drug	0.45
SIRT1	associated_with	gene	0.45
STING	associated_with	gene	0.45
BDNF	associated_with	gene	0.45
ALZHEIMER	associated_with	disease	0.45
NEURONS	associated_with	cell_type	0.45
AKT	associated_with	gene	0.45
CREB	associated_with	gene	0.45
ERK	associated_with	gene	0.45
HDAC2	associated_with	gene	0.45
N-ACETYLCYSTEINE	associated_with	drug	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SULFORAPHANE

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

CBS/PSP Supplements Guide

CBS/PSP Rehabilitation Master Guide

Therapeutics

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

CBS/PSP Treatment Rankings

NRF2 Oxidative Stress Pathway

oxidative-stress-comparison

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Sulforaphane and Nrf2 Activation for Neuroprotection

dimethyl-fumarate-nrf2-ad-nct06850597

Neuroprotection Strategies in Neurodegeneration

Curcumin for Neurodegeneration

Peroxisome Pathway in Neurodegeneration

Lipid Peroxidation in Neurodegeneration