gene 1,929 words KG: MEF2C
Contents

MEF2C Gene

🧬 Gene Info
Gene SymbolMEF2C
Full NameMyocyte Enhancer Factor 2C
Chromosome5q14.1
Protein TypeTranscription Factor
Functionis a calcium-dependent transcription factor belonging to the MADS (MCM1, Agamous, Deficiens, serum response factor) box family of MEF2 proteins.
Molecular Weight~50 kDa
Exons15
PathwaysEffect on MEF2C
UniProt IDQ06413 (MEF2C)
NCBI Gene ID4208
Ensembl IDENSG00000081189
OMIM600662
GeneCardsMEF2C
Human Protein AtlasMEF2C
Protein ClassTranscription factor (MADS-box family)
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Cancer, Carcinoma
Known Drugs/Compoundsrapamycin
InteractionsNF2, NRF2, TFAM, HDAC4, TXN, MTOR
SciDEX HypothesesMEF2C-Dependent Synaptic Gene Regulation
KG Connections264 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48

Related Analyses (2)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Activity-dependent PGC-1α transcriptional program analysis
exploratory · proposed · Score: 0.80

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
CD2AP Gene — CD2-Associated Protein
gene · KG edge: associated_with
CASS4 — Cas Scaffold Protein Family Member 4
gene · KG edge: associated_with
BIN1 — Bridging Integrator 1
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MEF2C activates NF2
MEF2C associated_with PTK2B
MEF2C associated_with FERMT2
MEF2C associated_with RIN3
MEF2C associated_with ZCWPW1
MEF2C activates NRF2
MEF2C modulates microglial phenotype
MEF2C co_discussed NFKBIA
MEF2C co_discussed RBFOX2
MEF2C inhibits TFAM