gene 1,227 words KG: PINK1 2026-03-24
kind:genesection:genesstate:publishedevidence:strong
Contents

PINK1 — PTEN Induced Kinase 1

🧬 Gene Info
Gene SymbolPINK1
Full NamePTEN Induced Kinase 1
Chromosome1p36.12
Protein FamilySerine/threonine kinase family
Protein TypeKinase
Functionis a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene [@zheng2021].
Primary ExpressionMitochondrial outer membrane
Molecular Weight63 kDa
PathwaysAmyloid, Apoptosis, Autophagy, Chaperone, Cholesterol
UniProt IDQ9BXM7
NCBI Gene ID65018
Ensembl IDENSG00000158828
OMIM608309
GeneCardsPINK1
Human Protein AtlasPINK1
Associated DiseasesAD, ALI, ALS, APOPTOSIS, Aging
Known Drugs/CompoundsDEFERIPRONE, RAPAMYCIN, MELATONIN, THSG, Gastrodin, icaritin
InteractionsBCL2L13, NLRP3, ABCD3, FIP200, RTN3, SESN2
KG Connections3597 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Conditional CRISPR Kill Switches for Aberrant Protein Cleara
Score: 0.45
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.42
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (25)

Do PINK1/PARKIN pathway enhancements rescue excitatory neuro
neurodegeneration · failed
Do PINK1/PARKIN pathway enhancements rescue excitatory neuro
neurodegeneration · failed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (7)

s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40
MLCS Quantification in Parkinson's Disease
validation · proposed · Score: 0.40

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
AIF1 Gene
gene · KG edge: activates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: expressed_in
ABCD3 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

PINK1 associated_with RB1
PINK1 associated_with TFEB
PINK1 associated_with ULK1
PINK1 co_discussed RIPK3
PINK1 co_discussed TARDBP
PINK1 co_discussed TDP-43
PINK1 co_discussed STING
PINK1 mediates LC3
PINK1 regulates MITOCHONDRIAL_BIOGENESIS
PINK1 associated_with ASSOCIATIVE LEARNING