gene

CCT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

77Connections
0Hypotheses
0Analyses
50Outgoing
16Incoming

Summary

CCT2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 51 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCCT2
Full NameChaperonin Containing TCP1 Subunit 2 (Beta)
Chromosome12q15
Protein TypeChaperone
Functionencodes a protein with a molecular weight of approximately 57 kDa.
Molecular Weight~57 kDa
Amino Acids535 aa
Exons13
PathwaysAutophagy
UniProt IDP78371
NCBI Gene ID10576
Ensembl IDENSG00000137217
OMIM605587
GeneCardsCCT2
Human Protein AtlasCCT2
Associated DiseasesAls, Cancer, Inflammation
InteractionsGFAP, GRIA1, SNAP25, ACTG1, SNCA, GAPDH
KG Connections77 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CCT2 — AlphaFold P78371 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

cct2

gene · 1409 words

cct4

gene · 1101 words

cct6a

gene · 1021 words

cct7

gene · 1012 words

cct5

gene · 893 words

Pathway Diagram

graph TD
    CCT2["<b>CCT2</b>"]
    Parkinson{"Parkinson"}
    CCT2 -->|"therapeutic target"| Parkinson
    Alzheimer{"Alzheimer"}
    CCT2 -->|"therapeutic target"| Alzheimer
    Huntington{"Huntington"}
    CCT2 -->|"therapeutic target"| Huntington
    Ms{"Ms"}
    CCT2 -->|"therapeutic target"| Ms
    Als{"Als"}
    CCT2 -->|"associated with"| Als
    Cancer{"Cancer"}
    CCT2 -->|"associated with"| Cancer
    Inflammation{"Inflammation"}
    CCT2 -->|"associated with"| Inflammation
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    CCT2 -->|"therapeutic target"| ALZHEIMER_S_DISEASE
    GFAP["GFAP"]
    CCT2 -->|"interacts with"| GFAP
    GRIA1["GRIA1"]
    CCT2 -->|"interacts with"| GRIA1
    SNAP25["SNAP25"]
    CCT2 -->|"interacts with"| SNAP25
    ACTG1["ACTG1"]
    CCT2 -->|"interacts with"| ACTG1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"regulates"| CCT2
    HDAC6["HDAC6"]
    HDAC6 -->|"associated with"| CCT2
    TP53["TP53"]
    TP53 -->|"associated with"| CCT2
    LC3["LC3"]
    LC3 -->|"activates"| CCT2
    style CCT2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (61)

TargetRelationTypeStr
solid protein aggregatesassociated_withbiological_process0.90
Autophagyregulatespathway0.70
Parkinsontherapeutic_targetdisease0.65
Alzheimertherapeutic_targetdisease0.65
Huntingtontherapeutic_targetdisease0.65

Incoming (16)

SourceRelationTypeStr
AUTOPHAGYregulatesgene0.70
HDAC6associated_withgene0.60
TP53associated_withgene0.60
TAX1BP1regulatesgene0.60
UBIQUITINregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found