Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CCT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CCT2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 51 entities in the SciDEX knowledge graph.
| Gene Symbol | CCT2 |
| Full Name | Chaperonin Containing TCP1 Subunit 2 (Beta) |
| Chromosome | 12q15 |
| Protein Type | Chaperone |
| Function | encodes a protein with a molecular weight of approximately 57 kDa. |
| Molecular Weight | ~57 kDa |
| Amino Acids | 535 aa |
| Exons | 13 |
| Pathways | Autophagy |
| UniProt ID | P78371 |
| NCBI Gene ID | 10576 |
| Ensembl ID | ENSG00000137217 |
| OMIM | 605587 |
| GeneCards | CCT2 |
| Human Protein Atlas | CCT2 |
| Associated Diseases | Als, Cancer, Inflammation |
| Interactions | GFAP, GRIA1, SNAP25, ACTG1, SNCA, GAPDH |
| KG Connections | 77 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CCT2["<b>CCT2</b>"]
Parkinson{"Parkinson"}
CCT2 -->|"therapeutic target"| Parkinson
Alzheimer{"Alzheimer"}
CCT2 -->|"therapeutic target"| Alzheimer
Huntington{"Huntington"}
CCT2 -->|"therapeutic target"| Huntington
Ms{"Ms"}
CCT2 -->|"therapeutic target"| Ms
Als{"Als"}
CCT2 -->|"associated with"| Als
Cancer{"Cancer"}
CCT2 -->|"associated with"| Cancer
Inflammation{"Inflammation"}
CCT2 -->|"associated with"| Inflammation
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
CCT2 -->|"therapeutic target"| ALZHEIMER_S_DISEASE
GFAP["GFAP"]
CCT2 -->|"interacts with"| GFAP
GRIA1["GRIA1"]
CCT2 -->|"interacts with"| GRIA1
SNAP25["SNAP25"]
CCT2 -->|"interacts with"| SNAP25
ACTG1["ACTG1"]
CCT2 -->|"interacts with"| ACTG1
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"regulates"| CCT2
HDAC6["HDAC6"]
HDAC6 -->|"associated with"| CCT2
TP53["TP53"]
TP53 -->|"associated with"| CCT2
LC3["LC3"]
LC3 -->|"activates"| CCT2
style CCT2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| solid protein aggregates | associated_with | biological_process | 0.90 |
| Autophagy | regulates | pathway | 0.70 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Huntington | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Prion | therapeutic_target | disease | 0.65 |
| GFAP | interacts_with | gene | 0.60 |
| GRIA1 | interacts_with | gene | 0.60 |
| SNAP25 | interacts_with | gene | 0.60 |
| ACTG1 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| GAPDH | interacts_with | gene | 0.60 |
| MAPK1 | interacts_with | gene | 0.60 |
| PSMA3 | interacts_with | gene | 0.60 |
| SOX2 | interacts_with | gene | 0.60 |
| YWHAZ | interacts_with | gene | 0.60 |
| HSP90AB1 | interacts_with | gene | 0.60 |
| ACTB | interacts_with | gene | 0.60 |
| CDC42 | interacts_with | gene | 0.60 |
| ATP5A1 | interacts_with | gene | 0.60 |
| SOD1 | interacts_with | gene | 0.60 |
| EGFR | interacts_with | gene | 0.60 |
| GUSB | associated_with | gene | 0.60 |
| PTGS2 | associated_with | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| HSP90AA1 | associated_with | gene | 0.60 |
| STAT3 | associated_with | gene | 0.60 |
| VEGFA | associated_with | gene | 0.60 |
| ABCB1 | associated_with | gene | 0.60 |
| P62 | regulates | gene | 0.60 |
| NBR1 | regulates | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| TAX1BP1 | regulates | gene | 0.60 |
| NBR1 | activates | gene | 0.60 |
| P62 | activates | gene | 0.60 |
| TAX1BP1 | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| FN1 | interacts_with | gene | 0.60 |
| Blood-Brain Barrier | therapeutic_target | pathway | 0.60 |
| Mapk | interacts_with | pathway | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| NR1I2 | associated_with | gene | 0.60 |
| OXIDATIVE STRESS | associated_with | gene | 0.60 |
| Sphingolipid | associated_with | pathway | 0.60 |
| Oxidative Stress | associated_with | pathway | 0.60 |
| Mapk | associated_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AUTOPHAGY | regulates | gene | 0.70 |
| HDAC6 | associated_with | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| TAX1BP1 | regulates | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| NBR1 | regulates | gene | 0.60 |
| P62 | regulates | gene | 0.60 |
| SOX2 | interacts_with | gene | 0.60 |
| SNAP25 | interacts_with | gene | 0.60 |
| SOD1 | interacts_with | gene | 0.60 |
| ACTB | interacts_with | gene | 0.60 |
| ACTG1 | interacts_with | gene | 0.60 |
| ATP5A1 | interacts_with | gene | 0.60 |
| AND | activates | gene | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| LC3 | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||