gene 975 words KG: PSP 2026-03-21
kind:genesection:genesstate:published
Contents

PSP Gene - Persephin

🧬 Gene Info
Gene SymbolPSP
Full NamePersephin
Chromosome19q13.33
Protein FamilyGDNF family
FunctionPersephin mediates its effects through specific receptor interactions:
PathwaysDifferentiation
GeneCardsPSP
Human Protein AtlasPSP
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Dementia
InteractionsVPS29, MAPT, GAL, MTOR, TAU, NLGN1
KG Connections292 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (17)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (8)

Do tau strains or regional cellular environments primarily d
neurodegeneration · failed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (15)

s:** - Test tau spreading in AQP4 knockout vs wild-type mice
falsification · proposed · Score: 0.40
4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40
Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri
clinical · proposed · Score: 0.40
Brainstem Circuit Modulation for PSP
clinical · proposed · Score: 0.40

See Also (11)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: expressed_in
Dementia Australia
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
DUSP10 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PSP associated_with SP1
PSP associated_with APOE
PSP associated_with TAU
PSP associated_with KIF13A
PSP associated_with TRIM24
PSP associated_with STX6
PSP associated_with MAPT
PSP activates VPS29
PSP activates MAPT
PSP activates GAL