gene 963 words KG: SNRNP70
Contents

SNRNP70 Gene

🧬 Gene Info
Gene SymbolSNRNP70
Full NameSmall nuclear ribonucleoprotein 70kDa
Chromosome19q13.33
FunctionSNRNP70 (U1-70K, RNPU1L) is a core component of the U1 small nuclear ribonucleoprotein (snRNP) complex, which plays an essential role in pre-mRNA splicing
Molecular Weight70kDa
UniProt ID[P08621](https://www.uniprot.org/uniprot/P08621)
Ensembl IDENSG00000106462
GeneCardsSNRNP70
Human Protein AtlasSNRNP70
Early RecognitionThe U1 snRNP recognizes the 5' splice site before the 3' splice site is recognized.
Cross-intron RecognitionSNRNP70 helps bridge the 5' and 3' splice sites together.
CatalysisThe assembled spliceosome catalyzes two transesterification reactions to remove introns.
RecyclingSNRNP70 is released and recycled for new splicing events.
Associated DiseasesAD, ALI, Als, Alzheimer, Alzheimer's disease, disease
InteractionsAMYLOID, DNA, NTN1, NTN3, Proteins, PTN
KG Connections54 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (19)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
CYP46A1 Overexpression Gene Therapy
Score: 0.77
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Netrin-1 Gradient Restoration
Score: 0.59
Cryptic Exon Silencing Restoration
Score: 0.53
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_with
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: interacts_with
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: expressed_in
BAD Gene - BCL2-Associated Agonist of Cell Death
gene · KG edge: expressed_in
JUN Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TARDBP interacts_with SNRNP70
NTN1 interacts_with SNRNP70
SNRNP70 expressed_in JUN
SNRNP70 interacts_with NTN3
SNRNP70 interacts_with TARDBP
JUN associated_with SNRNP70
NTN3 interacts_with SNRNP70
JUN expressed_in SNRNP70
SNRNP70 interacts_with TAU
SNRNP70 associated_with TREM2

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