Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NTN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NTN3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, expressed in, implicated in. Associated with AD, ALI, ALS. Connected to 41 entities in the SciDEX knowledge graph.
| Gene Symbol | NTN3 |
| Full Name | Netrin 3 |
| Chromosome | 16p13.3 |
| Protein Type | Receptor |
| Function | Like other netrins, NTN3 exerts its effects through binding to two main receptor families |
| Primary Expression | the adult brain and may have roles in synaptic plasticity and repair |
| Molecular Weight | ~71 kDa |
| Amino Acids | 641 aa |
| UniProt ID | Q9Y2I2 |
| NCBI Gene ID | 4904 |
| Ensembl ID | ENSG00000118445 |
| OMIM | 603389 |
| GeneCards | NTN3 |
| Human Protein Atlas | NTN3 |
| Protein Length | 641 amino acids |
| Associated Diseases | AD, ALI, Als, Alzheimer, Alzheimer's disease, ILD |
| Interactions | SNRNP70, TARDBP, TAU, NTN1, Rb, AMYLOID |
| KG Connections | 49 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NTN3["<b>NTN3</b>"]
Alzheimer{"Alzheimer"}
NTN3 -->|"expressed in"| Alzheimer
Als{"Als"}
NTN3 -->|"expressed in"| Als
NTN3 -->|"associated with"| Als
NTN3 -->|"associated with"| Alzheimer
ALS{"ALS"}
NTN3 -->|"expressed in"| ALS
Endocytosis(["Endocytosis"])
NTN3 -->|"expressed in"| Endocytosis
Complement(["Complement"])
NTN3 -->|"expressed in"| Complement
Exocytosis(["Exocytosis"])
NTN3 -->|"expressed in"| Exocytosis
SNRNP70["SNRNP70"]
NTN3 -->|"interacts with"| SNRNP70
TARDBP["TARDBP"]
NTN3 -->|"interacts with"| TARDBP
Amyloid(["Amyloid"])
NTN3 -->|"interacts with"| Amyloid
NTN3 -->|"associated with"| Complement
TARDBP -->|"interacts with"| NTN3
NTN1["NTN1"]
NTN1 -->|"interacts with"| NTN3
SNRNP70 -->|"interacts with"| NTN3
JUN["JUN"]
JUN -->|"expressed in"| NTN3
DNA["DNA"]
DNA -->|"interacts with"| NTN3
JUN -->|"associated with"| NTN3
COMPLEMENT["COMPLEMENT"]
COMPLEMENT -->|"expressed in"| NTN3
PTN["PTN"]
PTN -->|"interacts with"| NTN3
AMYLOID["AMYLOID"]
AMYLOID -->|"interacts with"| NTN3
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"expressed in"| NTN3
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"expressed in"| NTN3
TAU["TAU"]
TAU -->|"interacts with"| NTN3
style NTN3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| SNRNP70 | interacts_with | gene | 0.60 |
| TARDBP | interacts_with | gene | 0.60 |
| TAU | interacts_with | gene | 0.60 |
| NTN1 | interacts_with | gene | 0.60 |
| JUN | expressed_in | gene | 0.60 |
| Rb | interacts_with | protein | 0.60 |
| Endocytosis | expressed_in | pathway | 0.60 |
| Complement | expressed_in | pathway | 0.60 |
| Exocytosis | expressed_in | pathway | 0.60 |
| Amyloid | interacts_with | pathway | 0.60 |
| Complement | associated_with | pathway | 0.60 |
| Endocytosis | associated_with | pathway | 0.60 |
| Exocytosis | associated_with | pathway | 0.60 |
| Protein Aggregation | associated_with | pathway | 0.60 |
| Protein Aggregation | expressed_in | pathway | 0.60 |
| COMPLEMENT | expressed_in | gene | 0.60 |
| AMYLOID | interacts_with | gene | 0.60 |
| PTN | interacts_with | gene | 0.60 |
| TAR | interacts_with | gene | 0.60 |
| AD | implicated_in | disease | 0.50 |
| ALI | implicated_in | disease | 0.50 |
| Als | implicated_in | disease | 0.50 |
| Alzheimer | implicated_in | disease | 0.50 |
| Alzheimer's disease | implicated_in | disease | 0.50 |
| ILD | implicated_in | disease | 0.50 |
| RA | implicated_in | disease | 0.50 |
| SS | implicated_in | disease | 0.50 |
| disease | implicated_in | disease | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| AMYLOID-β | interacts_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TARDBP | interacts_with | gene | 0.60 |
| NTN1 | interacts_with | gene | 0.60 |
| SNRNP70 | interacts_with | gene | 0.60 |
| JUN | expressed_in | gene | 0.60 |
| JUN | associated_with | gene | 0.60 |
| TAU | interacts_with | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| COMPLEMENT | expressed_in | gene | 0.60 |
| PTN | interacts_with | gene | 0.60 |
| AMYLOID | interacts_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | expressed_in | gene | 0.60 |
| ALZHEIMER | expressed_in | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||