gene

NTN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NTN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections
0Hypotheses
0Analyses
35Outgoing
14Incoming

Summary

NTN3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, expressed in, implicated in. Associated with AD, ALI, ALS. Connected to 41 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNTN3
Full NameNetrin 3
Chromosome16p13.3
Protein TypeReceptor
FunctionLike other netrins, NTN3 exerts its effects through binding to two main receptor families
Primary Expressionthe adult brain and may have roles in synaptic plasticity and repair
Molecular Weight~71 kDa
Amino Acids641 aa
UniProt IDQ9Y2I2
NCBI Gene ID4904
Ensembl IDENSG00000118445
OMIM603389
GeneCardsNTN3
Human Protein AtlasNTN3
Protein Length641 amino acids
Associated DiseasesAD, ALI, Als, Alzheimer, Alzheimer's disease, ILD
InteractionsSNRNP70, TARDBP, TAU, NTN1, Rb, AMYLOID
KG Connections49 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NTN3 — AlphaFold Q9Y2I2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

NTN3 Gene

gene · 1604 words

Protein Aggregation Seeding

mechanism · 3114 words

Axon Guidance in 4R-Tauopathies

mechanism · 2250 words

Axon Guidance Pathways in Neurodegeneration

mechanism · 2041 words

NTN3 Protein

protein · 1468 words

NTNG2

gene · 1312 words

Pathway Diagram

graph TD
    NTN3["<b>NTN3</b>"]
    Alzheimer{"Alzheimer"}
    NTN3 -->|"expressed in"| Alzheimer
    Als{"Als"}
    NTN3 -->|"expressed in"| Als
    NTN3 -->|"associated with"| Als
    NTN3 -->|"associated with"| Alzheimer
    ALS{"ALS"}
    NTN3 -->|"expressed in"| ALS
    Endocytosis(["Endocytosis"])
    NTN3 -->|"expressed in"| Endocytosis
    Complement(["Complement"])
    NTN3 -->|"expressed in"| Complement
    Exocytosis(["Exocytosis"])
    NTN3 -->|"expressed in"| Exocytosis
    SNRNP70["SNRNP70"]
    NTN3 -->|"interacts with"| SNRNP70
    TARDBP["TARDBP"]
    NTN3 -->|"interacts with"| TARDBP
    Amyloid(["Amyloid"])
    NTN3 -->|"interacts with"| Amyloid
    NTN3 -->|"associated with"| Complement
    TARDBP -->|"interacts with"| NTN3
    NTN1["NTN1"]
    NTN1 -->|"interacts with"| NTN3
    SNRNP70 -->|"interacts with"| NTN3
    JUN["JUN"]
    JUN -->|"expressed in"| NTN3
    DNA["DNA"]
    DNA -->|"interacts with"| NTN3
    JUN -->|"associated with"| NTN3
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"expressed in"| NTN3
    PTN["PTN"]
    PTN -->|"interacts with"| NTN3
    AMYLOID["AMYLOID"]
    AMYLOID -->|"interacts with"| NTN3
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"expressed in"| NTN3
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"expressed in"| NTN3
    TAU["TAU"]
    TAU -->|"interacts with"| NTN3
    style NTN3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (35)

TargetRelationTypeStr
Alzheimerexpressed_indisease0.65
Alsexpressed_indisease0.65
Alsassociated_withdisease0.65
Alzheimerassociated_withdisease0.65
ALSexpressed_indisease0.65

Incoming (14)

SourceRelationTypeStr
TARDBPinteracts_withgene0.60
NTN1interacts_withgene0.60
SNRNP70interacts_withgene0.60
JUNexpressed_ingene0.60
JUNassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found