protein

LAMP2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LAMP2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

1Analyses

26Outgoing

12Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	LAMP2B
Target Class	Signaling Protein
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: Microglia-Derived Extracellular Vesicle Engineering for Targeted Mitochondrial Delivery
Druggability	Low (0.40)
Clinical Stage	Phase I
Pathways	neurotrophin signaling, autophagy pathway
GeneCards	LAMP2B
Human Protein Atlas	LAMP2B
Associated Diseases	als, ms, neurodegeneration
Interactions	RAB27A, NMDAR, LAMP2
SciDEX Target	View Target Profile
KG Connections	38 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    LAMP2B["LAMP2B"] -->|"regulates"| autophagosome_lysosome_fusion["autophagosome-lysosome fusion"]
    style autophagosome_lysosome_fusion fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    LAMP2B["LAMP2B"] -->|"studied in"| neurodegeneration["neurodegeneration"]
    style neurodegeneration fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    LAMP2B["LAMP2B"] -->|"interacts"| RAB27A["RAB27A"]
    style RAB27A fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    LAMP2B["LAMP2B"] -->|"co discussed"| Synthetic_fusion_proteins["Synthetic fusion proteins"]
    style Synthetic_fusion_proteins fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    LAMP2B["LAMP2B"] -->|"co discussed"| GJA1["GJA1"]
    style GJA1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    RAB27A_1["RAB27A"] -->|"interacts"| LAMP2B["LAMP2B"]
    style RAB27A_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ChR2["ChR2"] -->|"co discussed"| LAMP2B["LAMP2B"]
    style ChR2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BNIP3L["BNIP3L"] -->|"co discussed"| LAMP2B["LAMP2B"]
    style BNIP3L fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    RHOT1["RHOT1"] -->|"co discussed"| LAMP2B["LAMP2B"]
    style RHOT1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PANX1["PANX1"] -->|"co discussed"| LAMP2B["LAMP2B"]
    style PANX1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style LAMP2B fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (26)

Target	Relation	Type	Str
Autophagosome-Lysosome Fusion	involved_in	process	0.95
Cardiomyocytes	expressed_in	cell_type	0.85
autophagosome-lysosome fusion	regulates	process	0.70
NMDA	regulates	gene	0.60
NMDAR	interacts_with	gene	0.60
neurotrophin signaling	participates_in	pathway	0.55
neurons	expressed_in	cell_type	0.55
RAB27A	associated_with	gene	0.55
autophagy pathway	participates_in	pathway	0.55
RAB27A	expressed_in	gene	0.55
microglia	expressed_in	cell_type	0.55
neurodegeneration	associated_with	disease	0.43
RAB27A	interacts_with	gene	0.43
Synthetic fusion proteins	co_discussed	gene	0.40
GJA1	co_discussed	gene	0.40
LAMP2	associated_with	gene	0.35
LAMP2A	associated_with	gene	0.35
ms	implicated_in	disease	0.35
als	implicated_in	disease	0.35
TARDBP	associated_with	gene	0.35
NMDA	associated_with	gene	0.35
DLG3	associated_with	gene	0.35
TAR	associated_with	gene	0.35
HTT	associated_with	gene	0.35
neurodegeneration	implicated_in	disease	0.35
NMDAR	associated_with	gene	0.35

Incoming (12)

Source	Relation	Type	Str
h-d78123d1	targets_gene	hypothesis	0.90
LAMP2	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
LAMP2	interacts_with	gene	0.60
BDNF	expressed_in	gene	0.55
RAB27A	interacts_with	gene	0.43
ChR2	co_discussed	gene	0.40
BNIP3L	co_discussed	gene	0.40
RHOT1	co_discussed	gene	0.40
PANX1	co_discussed	gene	0.40
RAB27A	co_discussed	gene	0.40
BNIP3	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between neurons and glia

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.450

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LAMP2B

Understanding Entity Pages

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Exosome and Extracellular Vesicle Brain Delivery

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

autophagy-lysosomal-alzheimers

Mitochondrial Support Strategies for CBS/PSP

Exosome-Based Drug Delivery for CBS/PSP

LAMP2A Protein — Lysosomal-Associated Membrane Protein 2A

LAMP2A Gene

Intrathecal and Intracerebroventricular Drug Delivery

Liposome and Lipid-Based Brain Delivery

Section 138: Advanced Extracellular Matrix and Integrin Therapy in CBS/PSP

Mitochondrial Dynamics Modulators for Neurodegenerative Diseases

iPSC-Derived Neurons for Drug Screening in CBS/PSP

Glial Cell Line-Derived Neurotrophic Factor (GDNF) Therapies

Microglia Modulation Therapies

LAMP2 Protein

Section 194: Advanced Membrane Trafficking and Vesicle Dynamics in CBS/PSP

Intranasal Brain Delivery

Microglia Depletion and Repopulation Therapy