gene 1,196 words KG: LCK
Contents

LCK — LCK Proto-Oncogene, Src Family Tyrosine Kinase

🧬 Gene Info
Gene SymbolLCK
Full NameLCK Proto-Oncogene, Src Family Tyrosine Kinase
AliasesLymphocyte-Specific Protein Tyrosine Kinase
Chromosome1p35.2
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionT-lymphocytes and is essential for T-cell receptor (TCR) signaling, playing a critical role in adaptive immunity PMID: 15035502
Subcellular Localizationthe cytoplasmic face of the plasma membrane. It is one of the earliest signaling molecules activated following TCR engag
Molecular Weight56 kDa
Exons12
PathwaysNF-κB
NCBI Gene ID15035502
Ensembl IDENSG00000182866
GeneCardsLCK
Human Protein AtlasLCK
Associated DiseasesAging, Als, Alzheimer
InteractionsACTB, APOPTOSIS, AUTOPHAGY, CAT, CCL5, CD19
KG Connections65 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (1)

Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53

Knowledge Graph (12 edges)

LCK activates FYN
LCK activates SRC
SRC activates LCK
FYN activates LCK
BCL2 therapeutic_target LCK
CD4 interacts_with LCK
MAPK3 interacts_with LCK
ZAP70 interacts_with LCK
TP53 interacts_with LCK
CD19 interacts_with LCK

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.