gene 515 words KG: ZAP70 2026-03-21
kind:genesection:genesstate:published
Contents

ZAP70 — Zeta Chain T-Cell Receptor Associated Protein Kinase 70

🧬 Gene Info
Gene SymbolZAP70
Full NameZeta Chain T-Cell Receptor Associated Protein Kinase 70
Chromosome2q11.82
Protein TypeKinase
Functionis a tyrosine kinase essential for T-cell receptor (TCR) signaling and adaptive immunity.
Ensembl IDENSG00000120217
GeneCardsZAP70
Human Protein AtlasZAP70
Associated Diseasesneurodegeneration
InteractionsTP53, CD19, EEF2, CCL5, TNF, TLR7
KG Connections39 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51

Related Analyses (12)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: biomarker_for
Packard Center for ALS Research
institution · KG edge: biomarker_for
Mitofusin 1 (MFN1)
gene · KG edge: biomarker_for
MAPK3 Gene - ERK1
gene · KG edge: interacts_with
LCK — LCK Proto-Oncogene, Src Family Tyrosine Kinase
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

ZAP70 interacts_with TP53
ZAP70 interacts_with CD19
ZAP70 interacts_with EEF2
ZAP70 interacts_with CCL5
ZAP70 interacts_with TNF
ZAP70 interacts_with TLR7
ZAP70 interacts_with CAT
ZAP70 interacts_with ACTB
ZAP70 interacts_with RAC2
ZAP70 interacts_with CTSD