| Gene Symbol | ZAP70 |
| Full Name | Zeta Chain T-Cell Receptor Associated Protein Kinase 70 |
| Chromosome | 2q11.82 |
| Protein Type | Kinase |
| Function | is a tyrosine kinase essential for T-cell receptor (TCR) signaling and adaptive immunity. |
| Ensembl ID | ENSG00000120217 |
| GeneCards | ZAP70 |
| Human Protein Atlas | ZAP70 |
| N-terminal tandem SH2 domains | Bind to phosphorylated ITAM motifs on TCR ζ-chain |
| Interdomain A | Regulatory region |
| Kinase domain | Catalytic activity (C-terminal) |
| C-terminal proline-rich region | Protein-protein interactions |
| LAT | Linker for activation of T cells |
| SLP-76 | Adapter protein |
| Vav | GEF for Rho family GTPases |
| Associated Diseases | neurodegeneration |
| Interactions | ACTB, CAT, CCL5, CD19, CD4, CDK4 |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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