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gene 3,823 words KG: LRRK2
Contents

LRRK2 — Leucine Rich Repeat Kinase 2

🧬 Gene Info
Gene SymbolLRRK2
Full NameLeucine Rich Repeat Kinase 2
Chromosome12q12
Protein TypeProtein
Subcellular LocalizationCytoplasmic vesicle, Perikaryon, Golgi apparatus membrane, Cell projection, axon, Cell projection, dendrite, Endoplasmic
Amino Acids2527 aa
PathwaysMAPK
UniProt IDSearch UniProt
GeneCardsLRRK2
Human Protein AtlasLRRK2
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsBIIB094, BIIB122, Cigarette Smoking, DNL201, Environmental Toxicants, levodopa
Interactions6-OHDA, ACETYLCHOLINE, ACHE, Actin, AD, AKT
SciDEX HypothesesLRRK2 G2019S Kinase Inhibition for Parkinson's Dis
G2019S primarily raises baseline LRRK2 kinase acti
Therapeutic Window Exists Because Amplified Signal (+6 more)
KG Connections2622 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (19)

LRRK2 G2019S Kinase Inhibition for Parkinson's Disease
Score: 0.80G2019S primarily raises baseline LRRK2 kinase activity rathe
Score: 0.79Therapeutic Window Exists Because Amplified Signals (Not Bas
Score: 0.78Mutant-dependent amplification is context-dependent and stro
Score: 0.74G2019S Acts as Lysosomal Volume-Sensing Amplifier via Enhanc
Score: 0.73LRRK2 kinase inhibition to normalize lysosomal trafficking i
Score: 0.71RAB29 Is the Critical Molecular Switch That Determines Wheth
Score: 0.71A downstream LRRK2-Rab10-JIP4 lysosomal stress loop promotes
Score: 0.68LRRK2 Volume Sensor Hijacking Drives Metabolic Dysregulation
Score: 0.67LRRK2 Haploinsufficiency Traps Microglia in Senescence-Like
Score: 0.65LRRK2 G2019S Uncouples RAB29-Dependent Spatial Control from
Score: 0.64LRRK2 Kinase Inhibition Reduces α-Synuclein Spread via Lysos
Score: 0.62Baseline Elevation from ER Stress Is Epiphenomenon, Not Lyso
Score: 0.59LYTL and JIP4-dependent lysosomal remodeling may show mutant
Score: 0.58G2019S Amplifies Lysosomal Volume-Sensing Through Membrane M
Score: 0.56TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosoma
Score: 0.56Dual-Mechanism Model: G2019S Increases Both Baseline AND Sig
Score: 0.55Vagus Nerve as Anatomical Highway for Prion-Like α-Syn Propa
Score: 0.44MiT-TFE/LRRK2 Lysosomal Enhancement Therapy
Score: 0.00

Knowledge Graph (12 edges)

OPTN interacts_with LRRK2
CASP3 interacts_with LRRK2
AKT1 interacts_with LRRK2
CALCOCO2 interacts_with LRRK2
CGAS interacts_with LRRK2
CFTR interacts_with LRRK2
SQSTM1 interacts_with LRRK2
RPS6KB1 interacts_with LRRK2
GRB2 interacts_with LRRK2
RHEB interacts_with LRRK2

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