gene 2,834 words KG: LRRK2 2026-03-24
kind:genesection:genesstate:publishedevidence:strong
Contents

LRRK2 — Leucine Rich Repeat Kinase 2

🧬 Gene Info
Gene SymbolLRRK2
Full NameLeucine Rich Repeat Kinase 2
Chromosome12q12
Protein TypeProtein
Primary ExpressionStriatum, Cerebral cortex, Kidney, Lungs
Amino Acids2527 aa
PathwaysMAPK
UniProt IDSearch UniProt
NCBI Gene ID120892
Ensembl IDENSG00000188906
OMIM609007
GeneCardsLRRK2
Human Protein AtlasLRRK2
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsRAPAMYCIN, levodopa, Cigarette Smoking, MLi-2, PF-06447475, Environmental Toxicants
InteractionsATG16L1, RB1CC1, GABARAP, ERN1, STAT3, IFNG
KG Connections2480 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Knowledge Graph (12 edges)

LRRK2 interacts_with ATG16L1
LRRK2 interacts_with RB1CC1
LRRK2 interacts_with GABARAP
LRRK2 interacts_with ERN1
LRRK2 interacts_with STAT3
LRRK2 interacts_with IFNG
LRRK2 interacts_with LC3
LRRK2 interacts_with RPTOR
LRRK2 interacts_with RB1
LRRK2 interacts_with EIF2AK3