mechanism 2,068 words KG: astrocyte
kind:mechanismsection:mechanismsstate:publishedtopic:parkinsons
Contents

Astrocyte Dysfunction in Parkinson's Disease

Mechanism Info
NameAstrocyte Dysfunction in Parkinson's Disease
SummaryMechanistic pathways by which astrocyte dysfunction contributes to Parkinson's disease pathogenesis, including metabolic failure, calcium dysregulation, and α-synuclein accumulation
Key Genes/ProteinsTNF, GJA1, GFAP, S100B, ALDH1L1, AQP4
Related DiseasesTemporal Lobe Epilepsy, Alzheimer's disease
Related Pathwaysproinflammatory cytokines
Linked Hypotheses26 hypotheses

Knowledge Graph

Related Hypotheses (30)

LRP1-Dependent Tau Uptake Disruption
Score: 0.44
SASP-Mediated Complement Cascade Amplification
Score: 0.70
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (30)

Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived

Related Experiments (30)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40

See Also (11)

ADORA1 Gene
gene · KG edge: activates
ADNP Gene
gene · KG edge: expressed_in
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: activates
ABCG4 Gene — ATP-Binding Cassette Subfamily G Member 4
gene · KG edge: expressed_in
ABCG1 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

astrocyte associated_with Multiple sclerosis
astrocyte associated_with neuron
astrocyte interacts_with neuron
astrocyte involved_in neurodegenerative stress response
astrocyte involved_in Temporal Lobe Epilepsy
astrocyte associated_with Alzheimer's disease
astrocyte implicated_in Alzheimer's disease
astrocyte co_discussed lysosome
MAP1LC3B expressed_in astrocyte
CB2R expressed_in astrocyte