| Name | Dorsolateral Prefrontal Cortex Executive Dysfunction in Alzheimer's Disease |
| Category | evidence:strong |
| Summary | Mechanistic model of how dorsolateral prefrontal cortex (DLPFC) dysfunction contributes to executive impairment in Alzheimer's Disease — covering layer-specific vulnerability, tau spreading patterns, working memory deficits, and relationship to cognitive reserve. |
| Key Genes/Proteins | PSD-95, SQSTM1 |
| Related Diseases | neurodegeneration, Alzheimer's disease |
| Related Pathways | glutamate signaling, unfolded protein response, oxidative stress response, autophagy pathway, ubiquitin-proteasome |
| Linked Hypotheses | 2 hypotheses |