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mechanism 2,596 words KG: JAK
Contents

JAK-STAT and Cytokine Signaling in 4R-Tauopathies

⚙ Mechanism Info
NameJAK
Key Genes/ProteinsABCB1, ABCG2, ABL1, ACHE, AD, AD RISK GENES
Related DiseasesAddiction, aging, Aging
Related PathwaysAdaptive Immunity, Akt
Linked Hypotheses4 hypotheses

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Wikipedia

Related Hypotheses (66)

Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67Temporal TET2-Mediated Hydroxymethylation Cycling
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Score: 0.62TREM2-Dependent Microglial Senescence Transition
Score: 0.62VCP-Mediated Autophagy Enhancement
Score: 0.59HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
← Prevpg 4/4

Related Analyses (28)

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Related Experiments (7)

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validation · proposed · Score: 0.45

See Also (15)

Retinal Degeneration Pathway in Neurodegeneration
mechanism · Pages share 6 hypothesesgp130/IL-6 Family Cytokine Signaling in Neurodegenerati
mechanism · Pages share 6 hypothesesIL-1 Signaling Pathway in Neurodegeneration
mechanism · Pages share 6 hypothesesMicroglial Priming Pathway in Neurodegeneration
mechanism · Pages share 6 hypothesesDown Syndrome Neurodegeneration Pathway
mechanism · Pages share 6 hypotheses

Knowledge Graph (12 edges)

IL6 activates JAK
JAK activates STAT3
JAK regulates CHROMATIN
JAK regulates GENE_EXPRESSION
JAK causes Alzheimer's disease
SOCS inhibits JAK
JAK associated_with JAK1
JAK associated_with JAK2
JAK associated_with STAT1
JAK associated_with MAPK

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