Contents

FAS Protein

🔬 Protein Info

Gene Symbol	FAS
Protein Family	TNF receptor superfamily
Protein Type	Receptor
Function	FAS (also known as CD95 or APO-1) is a cell surface receptor that triggers apoptosis upon binding with its ligand FASLG
Primary Expression	neurons and glial cells throughout the brain and plays roles in developmental apoptosis, immune surveillance, synaptic pruning, a
Subcellular Localization	Plasma membrane
Molecular Weight	43 kDa
Pathways	pathway: ### Activation Cascade
UniProt ID	P01375
GeneCards	FAS
Human Protein Atlas	FAS
Associated Diseases	AD, Als, Alzheimer, Alzheimer's disease, AMI
Interactions	A2M, ACETYL-COA, AGING, AKT, ALS, ALZHEIMER
KG Connections	605 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Knowledge Graph

NCSTN interacts_with FAS

FAS activates TNF

FAS interacts_with LMNA

FAS interacts_with APH1B

FAS interacts_with APOE

FAS activates IL6

FAS interacts_with SREBF1

FAS interacts_with PSEN2

FAS interacts_with A2M

FAS interacts_with DHCR24