| Gene Symbol | GPX4 |
| Full Name | Glutathione Peroxidase 4 |
| Aliases | GPX4PROTEIN |
| Chromosome | 19p13.3 |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | GPX4 serves as the primary defense against lipid peroxidation in cellular membranes |
| Mechanism of Action | Small molecule inhibitor or activator of peroxidase activity |
| Subcellular Localization | </b></td><td>Cytosol, mitochondria, nucleus</td></tr> |
| Druggability | Low (0.41) |
| Clinical Stage | Phase II |
| Molecular Weight | 22 kDa |
| Pathways | Akt, Apoptosis, Autophagy, Differentiation, Epigenetic |
| UniProt ID | P36969 |
| Ensembl ID | ENSG00000167468 |
| GeneCards | GPX4 |
| Human Protein Atlas | GPX4 |
| Associated Diseases | ALS, ALZHEIMER'S DISEASE, Alzheimer, Cancer, Carcinoma |
| Known Drugs/Compounds | NICOTINAMIDE, TEMOZOLOMIDE, N-ACETYLCYSTEINE, icariin, paricalcitol, curcumin |
| Interactions | SLC7A11, SOX9, MMP1, FER, TFR1, MLKL |
| SciDEX Target | View Target Profile (10 clinical trials) |
| SciDEX Hypotheses | Ferroptosis Inhibition for α-Synuclein Neuroprotec |
| KG Connections | 2167 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |