Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Copd: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | PAH, ATG, ROS, AUTOPHAGY, TNF, CFTR, TGFB1, MAP1LC3B |
| Therapeutic Agents | Byf |
| KG Connections | 127 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Copd["Copd"] -->|"activates"| Als["Als"]
Copd["Copd"] -->|"activates"| Inflammation["Inflammation"]
Copd["Copd"] -->|"regulates"| Als_1["Als"]
Copd["Copd"] -->|"therapeutic target"| Inflammation_2["Inflammation"]
Copd["Copd"] -.->|"inhibits"| Pi3K_Akt["Pi3K/Akt"]
Copd["Copd"] -->|"causes"| Oxidative_Stress["Oxidative Stress"]
Byf["Byf"] -->|"treats"| Copd["Copd"]
INFLAMMATION["INFLAMMATION"] -->|"activates"| Copd["Copd"]
INFLAMMATION_3["INFLAMMATION"] -->|"therapeutic target"| Copd["Copd"]
INFLAMMATION_4["INFLAMMATION"] -->|"regulates"| Copd["Copd"]
style Copd fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.85 |
| Inflammation | activates | disease | 0.75 |
| Als | regulates | disease | 0.75 |
| Inflammation | therapeutic_target | disease | 0.75 |
| Pi3K/Akt | inhibits | pathway | 0.70 |
| Oxidative Stress | causes | pathway | 0.70 |
| Immune Response | contributes_to | pathway | 0.70 |
| Oxidative Stress | therapeutic_target | pathway | 0.70 |
| Inflammation | regulates | disease | 0.65 |
| Inflammation | causes | disease | 0.65 |
| Lung Cancer | contributes_to | disease | 0.65 |
| Inflammation | contributes_to | disease | 0.65 |
| Mtor | associated_with | pathway | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Mapk | inhibits | pathway | 0.60 |
| Nf-Κb | inhibits | pathway | 0.60 |
| Immune Response | inhibits | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Senescence | activates | pathway | 0.60 |
| Nf-Κb | causes | pathway | 0.60 |
| Senescence | causes | pathway | 0.60 |
| Senescence | therapeutic_target | pathway | 0.60 |
| Oxidative Stress | associated_with | pathway | 0.60 |
| Epigenetic | contributes_to | pathway | 0.60 |
| Mtor | therapeutic_target | pathway | 0.60 |
| Autophagy | therapeutic_target | pathway | 0.60 |
| Dysbiosis | implicated_in | pathway | 0.60 |
| Ferroptosis | regulates | pathway | 0.60 |
| Mapk | therapeutic_target | pathway | 0.60 |
| Asthma | regulates | disease | 0.55 |
| Cystic Fibrosis | associated_with | disease | 0.55 |
| Pulmonary Fibrosis | associated_with | disease | 0.55 |
| Als | inhibits | disease | 0.55 |
| Inflammation | associated_with | disease | 0.55 |
| Aging | activates | disease | 0.55 |
| Als | expressed_in | disease | 0.55 |
| Als | contributes_to | disease | 0.55 |
| Asthma | contributes_to | disease | 0.55 |
| Pulmonary Fibrosis | contributes_to | disease | 0.55 |
| Aging | therapeutic_target | disease | 0.55 |
| Als | associated_with | disease | 0.55 |
| Fibrosis | associated_with | disease | 0.55 |
| Aging | inhibits | disease | 0.55 |
| Hepatitis | therapeutic_target | disease | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Byf | treats | drug | 0.95 |
| INFLAMMATION | activates | gene | 0.85 |
| INFLAMMATION | therapeutic_target | gene | 0.85 |
| INFLAMMATION | regulates | gene | 0.75 |
| AKT | inhibits | gene | 0.75 |
| PI3K | inhibits | gene | 0.75 |
| OXIDATIVE STRESS | causes | gene | 0.75 |
| INFLAMMATION | causes | gene | 0.75 |
| INFLAMMATION | contributes_to | gene | 0.75 |
| CANCER | contributes_to | gene | 0.75 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.75 |
| PAH | associated_with | gene | 0.65 |
| ATG | associated_with | gene | 0.65 |
| ROS | associated_with | gene | 0.65 |
| AUTOPHAGY | associated_with | gene | 0.65 |
| TNF | associated_with | gene | 0.65 |
| CFTR | associated_with | gene | 0.65 |
| TGFB1 | associated_with | gene | 0.65 |
| MAP1LC3B | associated_with | gene | 0.65 |
| MTOR | associated_with | gene | 0.65 |
| CYTOKINES | inhibits | gene | 0.65 |
| NF-ΚB | inhibits | gene | 0.65 |
| INFLAMMATION | associated_with | gene | 0.65 |
| AUTOPHAGY | activates | gene | 0.65 |
| APOPTOSIS | activates | gene | 0.65 |
| P62 | activates | gene | 0.65 |
| AGING | activates | gene | 0.65 |
| CYTOKINES | activates | gene | 0.65 |
| NF-ΚB | causes | gene | 0.65 |
| AGING | associated_with | gene | 0.65 |
| DNA | causes | gene | 0.65 |
| Cancer | contributes_to | disease | 0.65 |
| DNA | therapeutic_target | gene | 0.65 |
| DSDNA | therapeutic_target | gene | 0.65 |
| RAGE | regulates | gene | 0.65 |
| EGFR | regulates | gene | 0.65 |
| NAD | regulates | gene | 0.65 |
| SIRT1 | therapeutic_target | gene | 0.65 |
| P53 | regulates | gene | 0.65 |
| AGING | therapeutic_target | gene | 0.65 |
| DNA | activates | gene | 0.65 |
| OXIDATIVE STRESS | associated_with | gene | 0.65 |
| GENES | contributes_to | gene | 0.65 |
| CFTR | therapeutic_target | gene | 0.65 |
| PER | associated_with | gene | 0.65 |
| AUTOPHAGY | therapeutic_target | gene | 0.65 |
| MTOR | therapeutic_target | gene | 0.65 |
| GPX4 | causes | gene | 0.65 |
| KEAP1 | activates | gene | 0.65 |
| FERROPTOSIS | regulates | gene | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||