| Gene Symbol | GRM5 |
| Aliases | Page for GRM5 Gene |
| Protein Type | Receptor |
| Function | mGluR5 mediates modulatory glutamate signaling |
| Subcellular Localization | Plasma membrane, Dendritic spines |
| Molecular Weight | 132 kDa |
| Exons | 10 |
| Pathways | MAPK |
| UniProt ID | [P41594](https://www.uniprot.org/uniprot/P41594) |
| GeneCards | GRM5 |
| Human Protein Atlas | GRM5 |
| Venus flytrap domain (VFT) | Large extracellular N-terminal domain that binds glutamate |
| Cysteine-rich domain (CRD) | Connects VFT to transmembrane domain |
| Seven transmembrane domain (7TM) | Classic GPCR domain for G-protein coupling |
| Intracellular C-terminal tail | Contains phosphorylation sites and protein interaction motifs |
| Associated Diseases | Alzheimer, Autism, Bipolar, Cancer, Inflammation, Ms |
| Interactions | CACNA1B, CACNA1H, CDK5R2, DRD1, DRD2, FGF13 |
| SciDEX Hypotheses | Metabotropic Glutamate Receptor-Based Sleep Stabil |
| KG Connections | 118 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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