protein 1,067 words KG: GRM5 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

mGluR5 (Metabotropic Glutamate Receptor 5)

🔬 Protein Info
Gene SymbolGRM5
AliasesPage for GRM5 Gene
Protein TypeReceptor
FunctionmGluR5 mediates modulatory glutamate signaling
Subcellular LocalizationPlasma membrane, Dendritic spines
Molecular Weight132 kDa
Exons10
PathwaysMAPK
UniProt ID[P41594](https://www.uniprot.org/uniprot/P41594)
GeneCardsGRM5
Human Protein AtlasGRM5
Associated DiseasesAlzheimer, Autism, Bipolar, Cancer, Inflammation, Ms
InteractionsFGF13, CDK5R2, SLC17A7, GRIK4, SLC6A2, SLC1A1
KG Connections130 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.47
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.44
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (5)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (8)

Alzheimer Indonesia
institution · KG edge: associated_with
GABRA1 Gene
gene · KG edge: associated_with
FGF13 — Fibroblast Growth Factor 13
gene · KG edge: associated_with
DRD2 Gene
gene · KG edge: associated_with
DRD1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

GRM5 associated_with GABARAP
GRM5 associated_with GABRB1
GRM5 therapeutic_target SCN8A
GRM5 therapeutic_target STAT1
GRM5 therapeutic_target FGF13
GRM5 therapeutic_target SCN2B
GRM5 therapeutic_target CDK5R2
GRM5 therapeutic_target ISG15
GRM5 associated_with HTR2A
GRM5 associated_with GABRA1