protein 1,295 words KG: PINK1 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

PINK1 Protein

🔬 Protein Info
Gene SymbolPINK1
Chromosome1p36.12
Protein FamilySerine/threonine kinase family
Protein TypeKinase
Functionis a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene [@zheng2021].
Primary ExpressionMitochondrial outer membrane
Subcellular Localization</th><td>Mitochondrial inner membrane (OMM upon activation)</td></tr>
Molecular Weight63 kDa
PathwaysAmyloid, Apoptosis, Autophagy, Chaperone, Cholesterol
UniProt IDQ9BXM7
NCBI Gene ID65018
Ensembl IDENSG00000158828
OMIM608309
GeneCardsPINK1
Human Protein AtlasPINK1
Associated DiseasesAD, ALI, ALS, APOPTOSIS, Aging
Known Drugs/CompoundsDEFERIPRONE, RAPAMYCIN, MELATONIN, propionic acid, Ligustilide, BGP-15
InteractionsBCL2L13, NLRP3, ABCD3, FIP200, RTN3, SESN2
KG Connections3597 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Conditional CRISPR Kill Switches for Aberrant Protein Cleara
Score: 0.45
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.42
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (27)

Do PINK1/PARKIN pathway enhancements rescue excitatory neuro
neurodegeneration · failed
Do PINK1/PARKIN pathway enhancements rescue excitatory neuro
neurodegeneration · failed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (7)

s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
AIF1 Gene
gene · KG edge: activates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: expressed_in
ABCD3 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

PINK1 phosphorylates UBIQUITIN
PINK1 activates PARKIN
PINK1 recruits NDP52
PINK1 recruits OPTINEURIN
PINK1 interacts_with BCL2L13
PINK1 interacts_with NLRP3
PINK1 interacts_with ABCD3
PINK1 interacts_with FIP200
PINK1 interacts_with RTN3
PINK1 interacts_with SESN2