protein 1,224 words KG: PINK1 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

PINK1

🔬 Protein Info
Gene SymbolPINK1
Chromosome1p36.12
Protein FamilySerine/threonine kinase family
Protein TypeKinase
Functionis a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene [@zheng2021].
Primary ExpressionMitochondrial outer membrane
Subcellular LocalizationMitochondrial outer membrane
Molecular Weight63 kDa
PathwaysAmyloid, Apoptosis, Autophagy, Chaperone, Cholesterol
UniProt IDQ9BXM7
NCBI Gene ID65018
Ensembl IDENSG00000158828
OMIM608309
GeneCardsPINK1
Human Protein AtlasPINK1
Associated DiseasesAD, ALI, ALS, APOPTOSIS, Aging
Known Drugs/CompoundsDEFERIPRONE, RAPAMYCIN, MELATONIN, propionic acid, Ligustilide, BGP-15
InteractionsBCL2L13, NLRP3, ABCD3, FIP200, RTN3, SESN2
KG Connections3597 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Conditional CRISPR Kill Switches for Aberrant Protein Cleara
Score: 0.45
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.42
Senescent Cell Mitochondrial DNA Release
Score: 0.54
NLRP3/Mitophagy Coupling Modulation
Score: 0.52
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47

Related Analyses (25)

Do PINK1/PARKIN pathway enhancements rescue excitatory neuro
neurodegeneration · failed
Do PINK1/PARKIN pathway enhancements rescue excitatory neuro
neurodegeneration · failed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (7)

s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Selective Vulnerability of Dopaminergic Neurons — Mechanism
validation · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
AIF1 Gene
gene · KG edge: activates
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: expressed_in
ABCD3 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

PINK1 phosphorylates UBIQUITIN
PINK1 activates PARKIN
PINK1 recruits NDP52
PINK1 recruits OPTINEURIN
PINK1 interacts_with BCL2L13
PINK1 interacts_with NLRP3
PINK1 interacts_with ABCD3
PINK1 interacts_with FIP200
PINK1 interacts_with RTN3
PINK1 interacts_with SESN2