protein 1,356 words KG: STK11
Contents

STK11 Protein - LKB1 - Serine/Threonine Kinase 11

🔬 Protein Info
Gene SymbolSTK11
Full NameLKB1 (Serine/Threonine Kinase 11)
AliasesPage for STK11, Page for STK11 Protein
Chromosome19p13.3
Protein TypeProtein
Functionis a serine/threonine kinase that functions as a master regulator of cellular energy metabolism and stress responses.
Primary Expressionmammalian tissues with particularly high levels in the brain, liver, and skeletal muscle
Subcellular Localization[@zong2019]
Molecular Weight48.6 kDa
Amino Acids433 aa
Exons9
PathwaysAMPK, AMPK pathway, AMPK Pathway
UniProt IDSearch UniProt
GeneCardsSTK11
Human Protein AtlasSTK11
Associated DiseasesALS, Alzheimer, Cancer, multiple sclerosis, Parkinson
Known Drugs/CompoundsCrocetin, rapamycin
InteractionsACTB, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections289 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (12)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
APOE-Dependent Autophagy Restoration
Score: 0.89
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83
Lysosomal Positioning Dynamics Modulation
Score: 0.69
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.57
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57

Related Analyses (9)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
ACTB Gene
gene · KG edge: activates
ar
gene · KG edge: activates
ATG14 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

STK11 regulates PI3K_AKT_MTOR_pathway
ACTB regulates STK11
CDC42 regulates STK11
CASP3 regulates STK11
SQSTM1 associated_with STK11
TUBB3 associated_with STK11
STK11 associated_with VIM
STK11 regulates BECN1
STK11 associated_with HDAC6
STK11 regulates GAPDH

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