Contents

TFE3 Gene

🧬 Gene Info

Gene Symbol	TFE3
Function	is a member of the MiT/TFE family of basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factors, alongside TFEB, MITF, and TFEC.
Primary Expression	neurons, microglia, astrocytes, and oligodendrocytes - Double
Molecular Weight	59.5 kDa
Amino Acids	575 aa
Pathways	mTOR, mtor
Ensembl ID	ENSG00000068323
GeneCards	TFE3
Human Protein Atlas	TFE3
Lysosomal hydrolases	CTSD, CTSB, CTSL, HEXA, HEXB, GLA
Lysosomal membrane proteins	LAMP1, LAMP2, MCOLN1, ATP6V0D1, ATP6V1H
Autophagy regulators	BECN1, ATG9A, ATG16L1, WIPI1, ULK1
Lipid catabolism	PPARGC1A, LIPA, ASAH1
Macroautophagy	Upregulation of ATG genes for autophagosome formation
Chaperone-mediated autophagy (CMA)	Induction of LAMP2A and HSC70
Associated Diseases	ALS, Alzheimer, Kidney Cancer, Multiple Sclerosis, neurodegeneration, Parkinson
Known Drugs/Compounds	rapamycin
Interactions	Actin, AGING, AKT, AKT1, AKT1S1, AKT2
SciDEX Hypotheses	Selective TFEB Cofactor Enhancement
KG Connections	613 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Knowledge Graph