gene

TG2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

0Hypotheses

0Analyses

24Outgoing

12Incoming

0Experiments

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	TG2
Primary Expression	hippocampus
Pathways	oxidative stress response, unfolded protein response, autophagy pathway, blood-brain barrier
GeneCards	TG2
Human Protein Atlas	TG2
Associated Diseases	ALS, Alzheimer's disease, Huntington's disease, Parkinson's disease, neurodegeneration
Interactions	NFKB, PSP, ALS
KG Connections	36 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TG2["TG2"] -->|"associated"| INOS["INOS"]
    style INOS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TG2["TG2"] -->|"involved in"| Parkinson_S_Disease["Parkinson'S Disease"]
    style Parkinson_S_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    TG2["TG2"] -->|"involved in"| Alzheimer_S_Disease["Alzheimer'S Disease"]
    style Alzheimer_S_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    TG2["TG2"] -->|"activates"| neurodegeneration["neurodegeneration"]
    style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    TG2["TG2"] -->|"activates"| Huntington_s_disease["Huntington's disease"]
    style Huntington_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    TG2["TG2"] -->|"participates in"| oxidative_stress_response["oxidative stress response"]
    style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    TG2["TG2"] -->|"expressed in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Lipopolysaccharide["Lipopolysaccharide"] -->|"regulates"| TG2["TG2"]
    style Lipopolysaccharide fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| TG2["TG2"]
    style ASTROCYTES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ROS["ROS"] -->|"regulates"| TG2["TG2"]
    style ROS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    NFKB["NFKB"] -->|"activates"| TG2["TG2"]
    style NFKB fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PSP["PSP"] -->|"regulates"| TG2["TG2"]
    style PSP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style TG2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (24)

Target	Relation	Type	Str
INOS	associated_with	gene	0.85
Parkinson'S Disease	involved_in	disease	0.85
Alzheimer'S Disease	involved_in	disease	0.85
neurodegeneration	activates	disease	0.70
Huntington's disease	activates	disease	0.60
oxidative stress response	participates_in	pathway	0.60
astrocytes	expressed_in	cell_type	0.60
neurons	expressed_in	cell_type	0.60
hippocampus	expressed_in	brain_region	0.60
neurodegeneration	inhibits	disease	0.55
TGM2	associated_with	gene	0.55
neurodegeneration	associated_with	disease	0.55
Alzheimer's disease	implicated_in	disease	0.55
Parkinson's disease	implicated_in	disease	0.55
Huntington's disease	implicated_in	disease	0.55
ALS	implicated_in	disease	0.55
neurodegeneration	targets	disease	0.55
unfolded protein response	participates_in	pathway	0.55
tauopathy	regulates	disease	0.55
Parkinson's disease	regulates	disease	0.55
Huntington's disease	inhibits	disease	0.55
stem cells	expressed_in	cell_type	0.55
autophagy pathway	participates_in	pathway	0.55
blood-brain barrier	participates_in	pathway	0.55

Incoming (12)

Source	Relation	Type	Str
Lipopolysaccharide	upregulates	compound	0.95
ASTROCYTES	expressed_in	cell_type	0.90
ROS	regulates	process	0.85
NFKB	activates	gene	0.80
PSP	regulates	gene	0.60
PSP	inhibits	gene	0.60
PSP	associated_with	gene	0.60
GDNF	regulates	gene	0.60
C6	regulates	gene	0.60
ALS	implicated_in	gene	0.55
ALS	activates	gene	0.55
PSP	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TG2

Understanding Entity Pages

Wiki Pages (6)

TGM6 Gene

c6

Transglutaminase 6 Protein

C6 Protein

NF-κB p105/p50 Protein