🧫
Tau Pathology Initiation Zone Identification
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-tau-path
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.901904Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['PSP'], 'diseases': ['Neurodegeneration']} |
| model_system | human |
| summary | # Tau Pathology Initiation Zone Identification ## Background and Rationale Progressive Supranuclear Palsy (PSP) is a devastating tauopathy characterized by abnormal accumulation of 4R-tau protein in n |
| replication_status | conflicting |
| methodology_notes | Phase 1 (Months 1-6): Recruit 120 PSP patients meeting MDS-PSP criteria across three phenotypes (PSP-RS n=50, PSP-P n=35, PSP-F n=35) and 40 healthy controls matched for age, sex, and education. Condu |
| primary_outcome | Map the spatial-temporal progression of tau pathology in PSP, identifying primary initiation sites in brainstem nuclei and establishing tau burden thresholds for early disease detection with >85% diag |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.901909'} |
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