acid_ceramidase

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acid_ceramidase

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wiki page Created: 2026-04-02T07:32:08 By: import Quality: 70% ✓ SciDEX ID: wiki-acid_ceramidase

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acid_ceramidase

▸Metadata

summary	A protein referenced in 3 knowledge graph relationships. Key connections: ASAH1 (gene) encodes; produces ceramide_sphingosine (mechanism); glucosylceramide_accumulation (mechanism) substrate_for.
archived_at	2026-05-13 16:31:36.170273-07
entity_type	protein
neurowiki_url	https://neurowiki.xyz/search?q=acid_ceramidase
_schema_version	1
archived_reason	wiki_page_missing

📊 Evidence Profile

Evidence Balance

+0%

Certainty

25%

Debates

Incoming

Outgoing

135

0 supporting 0 contradicting 0 neutral

View full evidence profile →

🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

This artifact has no version history yet.

Linked Artifacts (139)

mentions🕸acid_ceramidase produces ceramide_sphingosine80%

mentions🕸glucosylceramide_accumulation substrate_for acid_ceramidase80%

mentions🕸glucosylceramide_accumulation component_of acid_ceramidase80%

mentions🕸ASAH1 encodes acid_ceramidase80%

mentions🧪Selective Acid Sphingomyelinase Modulation Therapy70%

mentions🧪Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu50%

mentions🧪Lipid Droplet Dynamics as Phenotype Switches50%

mentions🧪Senescent Cell Mitochondrial DNA Release50%

mentions🧪TFAM overexpression creates mitochondrial donor-recipient gr50%

mentions🧪Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam50%

mentions🧪Microglial Efferocytosis Enhancement via GPR32 Superagonists50%

mentions🧪Reelin-Mediated Cytoskeletal Stabilization Protocol50%

mentions🧪Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar50%

mentions🧪Mechanosensitive Ion Channel Reprogramming50%

mentions🧪Glycine-Rich Domain Competitive Inhibition50%

mentions🧪The Glial Ketone Metabolic Shunt Hypothesis50%

mentions🧪GAP43-mediated tunneling nanotube stabilization enhances neu50%

mentions🧪R-Loop Resolution Enhancement Therapy50%

mentions🧪Phase-Separated Organelle Targeting50%

mentions🧪Retinal Vascular Microcirculation Rescue50%

mentions🧪Synthetic Biology BBB Endothelial Cell Reprogramming50%

mentions🧪Chaperone-Mediated APOE4 Refolding Enhancement50%

mentions🧪AMPK hypersensitivity in astrocytes creates enhanced mitocho50%

mentions🧪Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu50%

mentions🧪Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption50%

mentions🧪Stress Granule Phase Separation Modulators50%

mentions🧪Perforant Path Presynaptic Terminal Protection Strategy50%

mentions🧪Cross-Seeding Prevention Strategy50%

mentions🧪TET2-Mediated Demethylation Rejuvenation Therapy50%

mentions🧪RNA Granule Nucleation Site Modulation50%

mentions🧪Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics50%

mentions🧪DNMT1-Targeting Antisense Oligonucleotide Reset50%

mentions🧪KDM6A-Mediated H3K27me3 Rejuvenation50%

mentions🧪Epigenetic Memory Erasure via TET2 Activation50%

mentions🧪ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro50%

mentions🧪Optogenetic Control of Mitochondrial Transfer Networks50%

mentions🧪Bacterial Enzyme-Mediated Dopamine Precursor Synthesis50%

mentions🧪Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener50%

mentions🧪RAB27A-dependent extracellular vesicle engineering for mitoc50%

mentions🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK50%

mentions🧪Synaptic Vesicle Tau Capture Inhibition50%

mentions🧪APOE-Dependent Autophagy Restoration50%

mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy50%

mentions🧪Circadian-Synchronized LRP1 Pathway Activation50%

mentions🧪Senescence-Associated Myelin Lipid Remodeling50%

mentions🧪Metabolic Circuit Breaker via Lipid Droplet Modulation50%

mentions🧪Astrocyte-Mediated Neuronal Epigenetic Rescue50%

mentions🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m50%

mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%

mentions🧪Sphingomyelin Synthase Activators for Raft Remodeling50%

mentions🧪TREM2-mediated microglial tau clearance enhancement50%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

mentions🧪Low Complexity Domain Cross-Linking Inhibition50%

mentions🧪Circadian-Gated Maresin Biosynthesis Amplification50%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

mentions🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation50%

mentions🧪Correcting Gut Microbial Dopamine Imbalance to Support Syste50%

mentions🧪Pharmacological Enhancement of APOE4 Glycosylation50%

mentions🧪Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro50%

mentions🧪Glial Glycocalyx Remodeling Therapy50%

mentions🧪Mitochondrial SPM Synthesis Platform Engineering50%

mentions🧪Metabolic Reprogramming via Microglial Glycolysis Inhibition50%

mentions🧪LRP1-Dependent Tau Uptake Disruption50%

mentions🧪Restoring Neuroprotective Tryptophan Metabolism via Targeted50%

mentions🧪Liquid-Liquid Phase Separation Modifier Therapy50%

mentions🧪Lysosomal Enzyme Trafficking Correction50%

mentions🧪Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution50%

mentions🧪Pericyte Contractility Reset via Selective PDGFR-β Agonism50%

mentions🧪Heat Shock Protein 70 Disaggregase Amplification50%

mentions🧪Targeted Butyrate Supplementation for Microglial Phenotype M50%

mentions🧪Enteric Nervous System Prion-Like Propagation Blockade50%

mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides50%

mentions🧪Mitochondrial Calcium Buffering Enhancement via MCU Modulati50%

mentions🧪Competitive APOE4 Domain Stabilization Peptides50%

mentions🧪Transcriptional Autophagy-Lysosome Coupling50%

mentions🧪Selective HDAC3 Inhibition with Cognitive Enhancement50%

mentions🧪Purinergic Signaling Polarization Control50%

mentions🧪Mitochondrial-Lysosomal Contact Site Engineering50%

mentions🧪Magnetosonic-Triggered Transferrin Receptor Clustering50%

mentions🧪Adenosine-Astrocyte Metabolic Reset50%

mentions🧪Senescence-Induced Lipid Peroxidation Spreading50%

mentions🧪Extracellular Vesicle Biogenesis Modulation50%

mentions🧪Proteostasis Enhancement via APOE Chaperone Targeting50%

mentions🧪Nutrient-Sensing Epigenetic Circuit Reactivation50%

mentions🧪Complement C1q Mimetic Decoy Therapy50%

mentions🧪Biorhythmic Interference via Controlled Sleep Oscillations50%

mentions🧪Gut Barrier Permeability-α-Synuclein Axis Modulation50%

mentions🧪Autophagosome Maturation Checkpoint Control50%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

mentions🧪Glymphatic System-Enhanced Antibody Clearance Reversal50%

mentions🧪Microbiome-Derived Tryptophan Metabolite Neuroprotection50%

mentions🧪APOE Isoform Expression Across Glial Subtypes50%

mentions🧪Circadian Rhythm Entrainment of Reactive Astrocytes50%

mentions🧪SASP-Driven Aquaporin-4 Dysregulation50%

mentions🧪Blood-Brain Barrier SPM Shuttle System50%

mentions🧪Digital Twin-Guided Metabolic Reprogramming50%

mentions🧪Circadian Glymphatic Rescue Therapy (Melatonin-focused)50%

mentions🧪Senescence-Activated NAD+ Depletion Rescue50%

mentions🧪Ganglioside Rebalancing Therapy50%

mentions🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th50%

mentions🧪Matrix Stiffness Normalization via Targeted Lysyl Oxidase In50%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

mentions🧪Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli50%

mentions🧪SASP-Mediated Cholinergic Synapse Disruption50%

mentions🧪Vagal Afferent Microbial Signal Modulation50%

mentions🧪CX43 hemichannel engineering enables size-selective mitochon50%

mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%

mentions🧪Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro50%

mentions🧪Noradrenergic-Tau Propagation Blockade50%

Reference URLs

Canonical (singular)/artifact/wiki-acid_ceramidasecanonical

Canonical (plural, REST)/artifacts/wiki-acid_ceramidasealias

API (JSON)/api/artifacts/wiki-acid_ceramidaseapi

Citation — BibTeX/artifacts/wiki-acid_ceramidase/cite?fmt=bibtexexport

Citation — RIS/artifacts/wiki-acid_ceramidase/cite?fmt=risexport

Citation — CSL-JSON/artifacts/wiki-acid_ceramidase/cite?fmt=cslexport

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