gene

CSNK2A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSNK2A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections
0Hypotheses
0Analyses
46Outgoing
14Incoming
0Experiments

Summary

CSNK2A1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Alzheimer. Connected to 40 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCSNK2A1
Chromosome20p13
FunctionCatalytic activity: α and α' subunits provide kinase activity
Primary Expressionhippocampus, cortex, and cerebellum
Amino Acids350 aa
Exons10
PathwaysNotch
Ensembl IDENSG00000101266
GeneCardsCSNK2A1
Human Protein AtlasCSNK2A1
Heterotetramer formationCombines with regulatory β subunits (CSNK2B) to form α₂β₂ or αα'β₂ holoenzymes
Constitutive activityUnlike most kinases, CK2 is constitutively active without requiring phosphorylation
Ubiquitous expressionHigh levels in brain, particularly in neurons
Ser202/Thr205AT8 epitope (also GSK3β, CDK5 targets)
Ser396/Ser404PHF-1 epitope
Associated DiseasesAls, Alzheimer, Alzheimer's Disease, Ms, Neurodegeneration, Parkinson
InteractionsTAU, HNRNPA2B1, NEURODEGENERATION, ALZHEIMER, ALZHEIMER'S DISEASE, Tau Protein
KG Connections60 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

CSNK2A1 Gene

gene · 788 words

HNRNPA2B1 Protein

protein · 5015 words

PICK1 - Protein Interacting With C Kinase 1

gene · 3315 words

CK2 Protein (Casein Kinase 2)

protein · 1265 words

HNRNPA2B1 - Heterogeneous Nuclear Ribonucleoprotein A2/B1

gene · 1258 words

CSNK2A2 Gene

gene · 736 words

Pathway Diagram

graph TD
    CSNK2A1["<b>CSNK2A1</b>"]
    Neurodegeneration{"Neurodegeneration"}
    CSNK2A1 -->|"activates"| Neurodegeneration
    Alzheimer{"Alzheimer"}
    CSNK2A1 -->|"activates"| Alzheimer
    Ms{"Ms"}
    CSNK2A1 -->|"activates"| Ms
    Als{"Als"}
    CSNK2A1 -->|"activates"| Als
    Parkinson{"Parkinson"}
    CSNK2A1 -->|"associated with"| Parkinson
    CSNK2A1 -->|"associated with"| Als
    CSNK2A1 -->|"associated with"| Ms
    CSNK2A1 -->|"associated with"| Alzheimer
    CSNK2A1 -->|"associated with"| Neurodegeneration
    ALS{"ALS"}
    CSNK2A1 -->|"activates"| ALS
    NOTCH1["NOTCH1"]
    CSNK2A1 -->|"regulates"| NOTCH1
    Notch(["Notch"])
    CSNK2A1 -->|"regulates"| Notch
    HNRNPA2B1["HNRNPA2B1"]
    HNRNPA2B1 -->|"activates"| CSNK2A1
    STX4["STX4"]
    STX4 -->|"associated with"| CSNK2A1
    LDLR["LDLR"]
    LDLR -->|"associated with"| CSNK2A1
    HSPB1["HSPB1"]
    HSPB1 -->|"associated with"| CSNK2A1
    APOA2["APOA2"]
    APOA2 -->|"associated with"| CSNK2A1
    LGALS3["LGALS3"]
    LGALS3 -->|"associated with"| CSNK2A1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| CSNK2A1
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    NEURODEGENERATIVE_DISORDERS -->|"associated with"| CSNK2A1
    DNA["DNA"]
    DNA -->|"regulates"| CSNK2A1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| CSNK2A1
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| CSNK2A1
    style CSNK2A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (46)

TargetRelationTypeStr
DNA Damageregulatesprocess0.85
Alzheimer's Diseaseassociated_withdisease0.75
Neurodegenerationcontributes_todisease0.75
Neural Progenitor Cellsexpressed_incell_type0.70
Neurodegenerationactivatesdisease0.65

Incoming (14)

SourceRelationTypeStr
HNRNPA2B1activatesgene0.60
STX4associated_withgene0.60
LDLRassociated_withgene0.60
APOA2associated_withgene0.60
LGALS3associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found