Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CSNK2A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CSNK2A1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Alzheimer. Connected to 40 entities in the SciDEX knowledge graph.
| Gene Symbol | CSNK2A1 |
| Chromosome | 20p13 |
| Function | Catalytic activity: α and α' subunits provide kinase activity |
| Primary Expression | hippocampus, cortex, and cerebellum |
| Amino Acids | 350 aa |
| Exons | 10 |
| Pathways | Notch |
| Ensembl ID | ENSG00000101266 |
| GeneCards | CSNK2A1 |
| Human Protein Atlas | CSNK2A1 |
| Heterotetramer formation | Combines with regulatory β subunits (CSNK2B) to form α₂β₂ or αα'β₂ holoenzymes |
| Constitutive activity | Unlike most kinases, CK2 is constitutively active without requiring phosphorylation |
| Ubiquitous expression | High levels in brain, particularly in neurons |
| Ser202/Thr205 | AT8 epitope (also GSK3β, CDK5 targets) |
| Ser396/Ser404 | PHF-1 epitope |
| Associated Diseases | Als, Alzheimer, Alzheimer's Disease, Ms, Neurodegeneration, Parkinson |
| Interactions | TAU, HNRNPA2B1, NEURODEGENERATION, ALZHEIMER, ALZHEIMER'S DISEASE, Tau Protein |
| KG Connections | 60 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CSNK2A1["<b>CSNK2A1</b>"]
Neurodegeneration{"Neurodegeneration"}
CSNK2A1 -->|"activates"| Neurodegeneration
Alzheimer{"Alzheimer"}
CSNK2A1 -->|"activates"| Alzheimer
Ms{"Ms"}
CSNK2A1 -->|"activates"| Ms
Als{"Als"}
CSNK2A1 -->|"activates"| Als
Parkinson{"Parkinson"}
CSNK2A1 -->|"associated with"| Parkinson
CSNK2A1 -->|"associated with"| Als
CSNK2A1 -->|"associated with"| Ms
CSNK2A1 -->|"associated with"| Alzheimer
CSNK2A1 -->|"associated with"| Neurodegeneration
ALS{"ALS"}
CSNK2A1 -->|"activates"| ALS
NOTCH1["NOTCH1"]
CSNK2A1 -->|"regulates"| NOTCH1
Notch(["Notch"])
CSNK2A1 -->|"regulates"| Notch
HNRNPA2B1["HNRNPA2B1"]
HNRNPA2B1 -->|"activates"| CSNK2A1
STX4["STX4"]
STX4 -->|"associated with"| CSNK2A1
LDLR["LDLR"]
LDLR -->|"associated with"| CSNK2A1
HSPB1["HSPB1"]
HSPB1 -->|"associated with"| CSNK2A1
APOA2["APOA2"]
APOA2 -->|"associated with"| CSNK2A1
LGALS3["LGALS3"]
LGALS3 -->|"associated with"| CSNK2A1
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"associated with"| CSNK2A1
NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
NEURODEGENERATIVE_DISORDERS -->|"associated with"| CSNK2A1
DNA["DNA"]
DNA -->|"regulates"| CSNK2A1
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"activates"| CSNK2A1
ALZHEIMER["ALZHEIMER"]
ALZHEIMER -->|"activates"| CSNK2A1
style CSNK2A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| DNA Damage | regulates | process | 0.85 |
| Alzheimer's Disease | associated_with | disease | 0.75 |
| Neurodegeneration | contributes_to | disease | 0.75 |
| Neural Progenitor Cells | expressed_in | cell_type | 0.70 |
| Neurodegeneration | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| NOTCH1 | regulates | gene | 0.60 |
| HNRNPA2B1 | associated_with | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| HNRNPA2B1 | activates | gene | 0.60 |
| LGALS3 | associated_with | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| Neural Progenitor | regulates | cell_type | 0.60 |
| STX4 | associated_with | gene | 0.60 |
| Notch | regulates | pathway | 0.60 |
| DNA | regulates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| HSPB1 | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| Stem Cell | regulates | cell_type | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| Tau Protein | activates | protein | 0.60 |
| App | activates | protein | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| Progenitor Cell | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| Stem Cell | expressed_in | cell_type | 0.55 |
| HNRNPA2B1 | co_discussed | gene | 0.50 |
| NOTCH1 | co_discussed | gene | 0.50 |
| TAU | co_discussed | protein | 0.50 |
| ALZHEIMER | regulates | gene | 0.50 |
| NEURON | co_discussed | gene | 0.50 |
| DNA DAMAGE | regulates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HNRNPA2B1 | activates | gene | 0.60 |
| STX4 | associated_with | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| APOA2 | associated_with | gene | 0.60 |
| LGALS3 | associated_with | gene | 0.60 |
| NOTCH1 | regulates | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| HSPB1 | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 0.60 |
| DNA | regulates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||