gene

RAB11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

238Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

RAB11 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, inhibits. Associated with ALS, Aging, Als. Connected to 98 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRAB11A
Full NameRAB11A, member RAS oncogene family
AliasesPage for RAB11A, Ras-Related Protein Rab-11A
Chromosome15q21.3
FunctionRAB11A functions in the recycling endosome compartment
Molecular Weight~24 kDa
Amino Acids216 aa
UniProt IDP62491
NCBI Gene ID8766
Ensembl IDENSG00000103740
OMIM609758
GeneCardsRAB11A
Human Protein AtlasRAB11A
Protein ClassRab GTPase
Associated DiseasesALS, Aging, Ftd, Neurodegeneration
InteractionsRAB5, C1Q, UBIQUITIN, APOE, C1Q/C3, COMPLEMENT
KG Connections238 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: RAB11 — AlphaFold P62491 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

RAB11A — Ras-Related Protein Rab-11A

gene · 1225 words

Autophagy Mechanisms

mechanism · 4866 words

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

mechanism · 4859 words

DCTN1 Protein (Dynactin Subunit 1)

protein · 3576 words

DNAJC13 — DnaJ Heat Shock Protein Family Member C13

gene · 3528 words

Endosomal Sorting Defects in Neurodegeneration

mechanism · 3248 words

Pathway Diagram

graph TD
    RAB11["RAB11"]
    RAB11 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    RAB11 -->|"target for"| Aging["Aging"]
    RAB11 -->|"target for"| Ms["Ms"]
    RAB11 -->|"target for"| Als["Als"]
    RAB11 -->|"target for"| STX17["STX17"]
    RAB11 -->|"inhibits"| RAB5["RAB5"]
    RAB11 -->|"target for"| SNAP29["SNAP29"]
    RAB11 -->|"target for"| IGF2BP1["IGF2BP1"]
    RAB11 -->|"target for"| LONP1["LONP1"]
    ELAVL2["ELAVL2"] -->|"target for"| RAB11
    C1Q["C1Q"] -->|"inhibits"| RAB11
    MTOR["MTOR"] -->|"target for"| RAB11
    CLPP["CLPP"] -->|"target for"| RAB11
    TFR1["TFR1"] -->|"regulates"| RAB11
    PI3K["PI3K"] -->|"target for"| RAB11
    BDNF["BDNF"] -->|"target for"| RAB11
    METTL3["METTL3"] -->|"target for"| RAB11
    AUTOPHAGY["AUTOPHAGY"] -->|"target for"| RAB11
    SNAP29 -->|"target for"| RAB11

Outgoing (137)

TargetRelationTypeStr
Neurodegenerationtherapeutic_targetdisease0.65
Agingtherapeutic_targetdisease0.65
Mstherapeutic_targetdisease0.65
Alstherapeutic_targetdisease0.65
Msregulatesdisease0.65

Incoming (101)

SourceRelationTypeStr
ELAVL2therapeutic_targetgene0.60
C1Qinhibitsgene0.60
MTORtherapeutic_targetgene0.60
CLPPtherapeutic_targetgene0.60
TFR1regulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found