Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB11 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, inhibits. Associated with ALS, Aging, Als. Connected to 98 entities in the SciDEX knowledge graph.
| Gene Symbol | RAB11A |
| Full Name | RAB11A, member RAS oncogene family |
| Aliases | Page for RAB11A, Ras-Related Protein Rab-11A |
| Chromosome | 15q21.3 |
| Function | RAB11A functions in the recycling endosome compartment |
| Molecular Weight | ~24 kDa |
| Amino Acids | 216 aa |
| UniProt ID | P62491 |
| NCBI Gene ID | 8766 |
| Ensembl ID | ENSG00000103740 |
| OMIM | 609758 |
| GeneCards | RAB11A |
| Human Protein Atlas | RAB11A |
| Protein Class | Rab GTPase |
| Associated Diseases | ALS, Aging, Ftd, Neurodegeneration |
| Interactions | RAB5, C1Q, UBIQUITIN, APOE, C1Q/C3, COMPLEMENT |
| KG Connections | 238 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RAB11["RAB11"]
RAB11 -->|"target for"| Neurodegeneration["Neurodegeneration"]
RAB11 -->|"target for"| Aging["Aging"]
RAB11 -->|"target for"| Ms["Ms"]
RAB11 -->|"target for"| Als["Als"]
RAB11 -->|"target for"| STX17["STX17"]
RAB11 -->|"inhibits"| RAB5["RAB5"]
RAB11 -->|"target for"| SNAP29["SNAP29"]
RAB11 -->|"target for"| IGF2BP1["IGF2BP1"]
RAB11 -->|"target for"| LONP1["LONP1"]
ELAVL2["ELAVL2"] -->|"target for"| RAB11
C1Q["C1Q"] -->|"inhibits"| RAB11
MTOR["MTOR"] -->|"target for"| RAB11
CLPP["CLPP"] -->|"target for"| RAB11
TFR1["TFR1"] -->|"regulates"| RAB11
PI3K["PI3K"] -->|"target for"| RAB11
BDNF["BDNF"] -->|"target for"| RAB11
METTL3["METTL3"] -->|"target for"| RAB11
AUTOPHAGY["AUTOPHAGY"] -->|"target for"| RAB11
SNAP29 -->|"target for"| RAB11| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | therapeutic_target | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ftd | associated_with | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Atherosclerosis | activates | disease | 0.65 |
| Ftd | therapeutic_target | disease | 0.65 |
| Neurodegeneration | expressed_in | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Glioblastoma | regulates | disease | 0.65 |
| Als | contributes_to | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| ALS | contributes_to | disease | 0.65 |
| Aging | encodes | disease | 0.65 |
| Neurodegeneration | encodes | disease | 0.65 |
| Als | encodes | disease | 0.65 |
| STX17 | therapeutic_target | gene | 0.60 |
| RAB5 | inhibits | gene | 0.60 |
| SNAP29 | therapeutic_target | gene | 0.60 |
| IGF2BP1 | therapeutic_target | gene | 0.60 |
| LONP1 | therapeutic_target | gene | 0.60 |
| BDNF | therapeutic_target | gene | 0.60 |
| FUS | therapeutic_target | gene | 0.60 |
| C1Q | inhibits | gene | 0.60 |
| AKT | therapeutic_target | gene | 0.60 |
| PI3K | associated_with | gene | 0.60 |
| STX17 | associated_with | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| IGF2BP1 | associated_with | gene | 0.60 |
| ELAVL2 | associated_with | gene | 0.60 |
| SNAP29 | associated_with | gene | 0.60 |
| LONP1 | associated_with | gene | 0.60 |
| CLPP | associated_with | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| APOE | activates | gene | 0.60 |
| C1Q/C3 | inhibits | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| CLPP | therapeutic_target | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| TRKB | expressed_in | gene | 0.60 |
| CACNA1G | expressed_in | gene | 0.60 |
| BDNF | expressed_in | gene | 0.60 |
| SLC17A7 | expressed_in | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ELAVL2 | therapeutic_target | gene | 0.60 |
| C1Q | inhibits | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| CLPP | therapeutic_target | gene | 0.60 |
| TFR1 | regulates | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| BDNF | therapeutic_target | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| SNAP29 | therapeutic_target | gene | 0.60 |
| IGF2BP1 | therapeutic_target | gene | 0.60 |
| FUS | therapeutic_target | gene | 0.60 |
| AKT | therapeutic_target | gene | 0.60 |
| LONP1 | therapeutic_target | gene | 0.60 |
| RAB5 | inhibits | gene | 0.60 |
| STX17 | therapeutic_target | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| FUS | associated_with | gene | 0.60 |
| C1Q/C3 | inhibits | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| IGF2BP1 | associated_with | gene | 0.60 |
| STX17 | associated_with | gene | 0.60 |
| SNAP29 | associated_with | gene | 0.60 |
| PI3K | associated_with | gene | 0.60 |
| LONP1 | associated_with | gene | 0.60 |
| CLPP | associated_with | gene | 0.60 |
| LDLR | activates | gene | 0.60 |
| TDP-43 | associated_with | gene | 0.60 |
| TDP-43 | therapeutic_target | gene | 0.60 |
| SLC17A7 | expressed_in | gene | 0.60 |
| RAB7 | expressed_in | gene | 0.60 |
| AKT | expressed_in | gene | 0.60 |
| RAB5 | expressed_in | gene | 0.60 |
| CACNA1G | expressed_in | gene | 0.60 |
| CALB1 | expressed_in | gene | 0.60 |
| GBM | regulates | gene | 0.60 |
| EGFR | regulates | gene | 0.60 |
| BIN1 | associated_with | gene | 0.60 |
| ELAVL2 | encodes | gene | 0.60 |
| SNAP29 | encodes | gene | 0.60 |
| FUS | encodes | gene | 0.60 |
| TDP-43 | encodes | gene | 0.60 |
| STX17 | encodes | gene | 0.60 |
| CLPP | encodes | gene | 0.60 |
| BDNF | encodes | gene | 0.60 |
| IGF2BP1 | encodes | gene | 0.60 |
| TRKB | expressed_in | gene | 0.60 |
| METTL3 | therapeutic_target | gene | 0.60 |
| AUTOPHAGY | therapeutic_target | gene | 0.60 |
| ALS | therapeutic_target | gene | 0.60 |
| AGING | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||