Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CDH5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| RELN | regulates | protein | 0.95 |
| Reln Secretion | mediates | process | 0.95 |
| Lymphatic Endothelial Cell | expressed_in | cell_type | 0.95 |
| reelin secretion | involved_in | process | 0.95 |
| Lymphatic Cell Permeability | modulates | phenotype | 0.90 |
| Cytoskeletal Remodeling | modulates | process | 0.90 |
| Adherens Junction Remodeling | involved_in | process | 0.90 |
| Lymphatic Endothelial Cell Permeability | modulates | phenotype | 0.90 |
| RELN | mediates | protein | 0.90 |
| tight junctional complex | involved_in | pathway | 0.90 |
| blood-brain barrier | involved_in | process | 0.90 |
| ADM | interacts_with | protein | 0.85 |
| Exocyst Complex | interacts_with | protein | 0.85 |
| Lymphatic Endothelial Cell Secretion | associated_with | process | 0.85 |
| ARF6 | interacts_with | protein | 0.85 |
| cytoskeletal remodeling | regulates | process | 0.80 |
| CLDN5 | associated_with | gene | 0.60 |
| CREBBP | regulates | gene | 0.60 |
| CTNNB1 | regulates | gene | 0.60 |
| EP300 | regulates | gene | 0.60 |
| FOXM1 | regulates | gene | 0.60 |
| MUC1 | regulates | gene | 0.60 |
| MUC16 | regulates | gene | 0.60 |
| SMARCA4 | regulates | gene | 0.60 |
| ROS | activates | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| epigenetic regulation | participates_in | pathway | 0.60 |
| benchmark_ot_ad_answer_key:CDH5 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| EXOC1 | interacts_with | protein | 0.90 |
| ARF6 | interacts_with | protein | 0.90 |
| Paeoniflorin | upregulates | compound | 0.88 |
| adrenomedullin | modulates | protein | 0.85 |
| ARF6 | regulates | gene | 0.85 |
| exocyst complex | mediates | protein | 0.80 |
| Qingqi Liangying formula | upregulates | drug | 0.80 |
| ANGPT1 | associated_with | gene | 0.60 |
| APC | regulates | gene | 0.60 |
| AXIN1 | regulates | gene | 0.60 |
| AXIN2 | regulates | gene | 0.60 |
| BRG1 | regulates | gene | 0.60 |
| CBP | regulates | gene | 0.60 |
| CDH1 | regulates | gene | 0.60 |
| benchmark_ot_ad_answer_key:CDH5 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||