Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EPG5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | EPG5 |
| Full Name | Ectopic P-Granules 5 Autophagy Tutor |
| Aliases | Page for EPG5 Gene |
| Chromosome | 18q12.3 |
| Function | Autophagosome maturation: EPG5 promotes the maturation of autophagosomes by facilitating their fusion with lysosomes |
| Primary Expression | Cerebral cortex, Brain stem, Spinal cord, Testis, Heart |
| Molecular Weight | 282 kDa |
| Amino Acids | 2573 aa |
| Exons | 36 |
| Pathways | Autophagy |
| UniProt ID | Q9H7D3 |
| NCBI Gene ID | 2058 |
| Ensembl ID | ENSG00000151692 |
| OMIM | 614921 |
| GeneCards | EPG5 |
| Human Protein Atlas | EPG5 |
| Associated Diseases | Glioblastoma, Tumor |
| Interactions | SQSTM1, LAMP2, SNARE, MAP1LC3, GLIOBLASTOMA, TGM2 |
| KG Connections | 82 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
EPG5["<b>EPG5</b>"]
Autophagosome_Lysosome_Fusion(["Autophagosome-Lysosome Fusion"])
EPG5 -->|"mediates"| Autophagosome_Lysosome_Fusion
Glioblastoma{"Glioblastoma"}
EPG5 -->|"associated with"| Glioblastoma
Tumor{"Tumor"}
EPG5 -->|"associated with"| Tumor
EPG5 -->|"regulates"| Tumor
STX17["STX17"]
EPG5 -->|"associated with"| STX17
SQSTM1["SQSTM1"]
EPG5 -->|"associated with"| SQSTM1
SNAP29["SNAP29"]
EPG5 -->|"associated with"| SNAP29
SDC1["SDC1"]
EPG5 -->|"associated with"| SDC1
TGM2["TGM2"]
EPG5 -->|"associated with"| TGM2
Autophagy(["Autophagy"])
EPG5 -->|"associated with"| Autophagy
LC3["LC3"]
EPG5 -->|"associated with"| LC3
GBM["GBM"]
EPG5 -->|"associated with"| GBM
VAMP8["VAMP8"]
VAMP8 -->|"associated with"| EPG5
LAMP2["LAMP2"]
LAMP2 -->|"associated with"| EPG5
GBM -->|"associated with"| EPG5
LC3 -->|"associated with"| EPG5
SQSTM1 -->|"associated with"| EPG5
SDC1 -->|"associated with"| EPG5
MAP1LC3["MAP1LC3"]
MAP1LC3 -->|"associated with"| EPG5
P62["P62"]
P62 -->|"associated with"| EPG5
SNAP29 -->|"associated with"| EPG5
STX17 -->|"associated with"| EPG5
TGM2 -->|"associated with"| EPG5
GFP["GFP"]
GFP -->|"associated with"| EPG5
style EPG5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagosome-Lysosome Fusion | mediates | process | 0.90 |
| Glioblastoma | associated_with | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| Glioblastoma | regulates | disease | 0.65 |
| STX17 | associated_with | gene | 0.60 |
| SQSTM1 | associated_with | gene | 0.60 |
| SNAP29 | associated_with | gene | 0.60 |
| SDC1 | associated_with | gene | 0.60 |
| TGM2 | associated_with | gene | 0.60 |
| LC3 | associated_with | gene | 0.60 |
| GBM | associated_with | gene | 0.60 |
| LAMP2 | associated_with | gene | 0.60 |
| P62 | associated_with | gene | 0.60 |
| VAMP8 | associated_with | gene | 0.60 |
| SDC1 | mediates | entity | 0.60 |
| TGM2 | mediates | entity | 0.60 |
| LC3 | interacts_with | entity | 0.60 |
| SDC1 | interacts_with | entity | 0.60 |
| SNAP29 | interacts_with | entity | 0.60 |
| STX17 | interacts_with | entity | 0.60 |
| TGM2 | interacts_with | entity | 0.60 |
| VAMP8 | interacts_with | entity | 0.60 |
| GBM | therapeutic_target | entity | 0.60 |
| SDC1 | therapeutic_target | entity | 0.60 |
| TGM2 | therapeutic_target | entity | 0.60 |
| GBM | regulates | entity | 0.60 |
| LAMP2 | regulates | entity | 0.60 |
| LC3 | regulates | entity | 0.60 |
| P62 | regulates | entity | 0.60 |
| SDC1 | regulates | entity | 0.60 |
| SNAP29 | regulates | entity | 0.60 |
| SQSTM1 | regulates | entity | 0.60 |
| STX17 | regulates | entity | 0.60 |
| TGM2 | regulates | entity | 0.60 |
| VAMP8 | regulates | entity | 0.60 |
| SDC1 | binds_to | gene | 0.60 |
| STX17 | binds_to | gene | 0.60 |
| TGM2 | binds_to | gene | 0.60 |
| SNAP29 | binds_to | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| MAP1LC3 | associated_with | gene | 0.60 |
| GLIOBLASTOMA | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| GLIOBLASTOMA | regulates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| AND | associated_with | gene | 0.60 |
| Actin | associated_with | protein | 0.60 |
| Fus | regulates | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| VAMP8 | associated_with | gene | 0.60 |
| LAMP2 | associated_with | gene | 0.60 |
| GBM | associated_with | gene | 0.60 |
| LC3 | associated_with | gene | 0.60 |
| SQSTM1 | associated_with | gene | 0.60 |
| SDC1 | associated_with | gene | 0.60 |
| P62 | associated_with | gene | 0.60 |
| SNAP29 | associated_with | gene | 0.60 |
| STX17 | associated_with | gene | 0.60 |
| TGM2 | associated_with | gene | 0.60 |
| GBM | regulates | gene | 0.60 |
| TGM2 | regulates | gene | 0.60 |
| SDC1 | regulates | gene | 0.60 |
| TGM2 | interacts_with | protein | 0.60 |
| MAP1LC3 | associated_with | gene | 0.60 |
| GFP | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| GLIOBLASTOMA | associated_with | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| Autophagy | interacts_with | process | 0.50 |
| autophagy | co_mentioned | pathway | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||