gene

EPG5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPG5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

82Connections
0Hypotheses
0Analyses
50Outgoing
21Incoming

Summary

Page for EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

View on Wiki →

🧬 Gene Info
Gene SymbolEPG5
Full NameEctopic P-Granules 5 Autophagy Tutor
AliasesPage for EPG5 Gene
Chromosome18q12.3
FunctionAutophagosome maturation: EPG5 promotes the maturation of autophagosomes by facilitating their fusion with lysosomes
Primary ExpressionCerebral cortex, Brain stem, Spinal cord, Testis, Heart
Molecular Weight282 kDa
Amino Acids2573 aa
Exons36
PathwaysAutophagy
UniProt IDQ9H7D3
NCBI Gene ID2058
Ensembl IDENSG00000151692
OMIM614921
GeneCardsEPG5
Human Protein AtlasEPG5
Associated DiseasesGlioblastoma, Tumor
InteractionsSQSTM1, LAMP2, SNARE, MAP1LC3, GLIOBLASTOMA, TGM2
KG Connections82 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: EPG5 — AlphaFold Q9H7D3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

gene · 3160 words

VAMP8 — Vesicle Associated Membrane Protein 8

gene · 2502 words

STX17 Gene

gene · 2405 words

mHTT Clearance Mechanisms in Huntington's Disease

mechanism · 1790 words

SNAP29 — Synaptosomal-Associated Protein 29

gene · 992 words

EPG5 Protein

protein · 652 words

Pathway Diagram

graph TD
    EPG5["<b>EPG5</b>"]
    Autophagosome_Lysosome_Fusion(["Autophagosome-Lysosome Fusion"])
    EPG5 -->|"mediates"| Autophagosome_Lysosome_Fusion
    Glioblastoma{"Glioblastoma"}
    EPG5 -->|"associated with"| Glioblastoma
    Tumor{"Tumor"}
    EPG5 -->|"associated with"| Tumor
    EPG5 -->|"regulates"| Tumor
    STX17["STX17"]
    EPG5 -->|"associated with"| STX17
    SQSTM1["SQSTM1"]
    EPG5 -->|"associated with"| SQSTM1
    SNAP29["SNAP29"]
    EPG5 -->|"associated with"| SNAP29
    SDC1["SDC1"]
    EPG5 -->|"associated with"| SDC1
    TGM2["TGM2"]
    EPG5 -->|"associated with"| TGM2
    Autophagy(["Autophagy"])
    EPG5 -->|"associated with"| Autophagy
    LC3["LC3"]
    EPG5 -->|"associated with"| LC3
    GBM["GBM"]
    EPG5 -->|"associated with"| GBM
    VAMP8["VAMP8"]
    VAMP8 -->|"associated with"| EPG5
    LAMP2["LAMP2"]
    LAMP2 -->|"associated with"| EPG5
    GBM -->|"associated with"| EPG5
    LC3 -->|"associated with"| EPG5
    SQSTM1 -->|"associated with"| EPG5
    SDC1 -->|"associated with"| EPG5
    MAP1LC3["MAP1LC3"]
    MAP1LC3 -->|"associated with"| EPG5
    P62["P62"]
    P62 -->|"associated with"| EPG5
    SNAP29 -->|"associated with"| EPG5
    STX17 -->|"associated with"| EPG5
    TGM2 -->|"associated with"| EPG5
    GFP["GFP"]
    GFP -->|"associated with"| EPG5
    style EPG5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (61)

TargetRelationTypeStr
Autophagosome-Lysosome Fusionmediatesprocess0.90
Glioblastomaassociated_withdisease0.65
Tumorassociated_withdisease0.65
Tumorregulatesdisease0.65
Glioblastomaregulatesdisease0.65

Incoming (21)

SourceRelationTypeStr
VAMP8associated_withgene0.60
LAMP2associated_withgene0.60
GBMassociated_withgene0.60
LC3associated_withgene0.60
SQSTM1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found