gene

VAMP8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VAMP8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

457Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Comprehensive page for VAMP8 (Vesicle Associated Membrane Protein 8), a SNARE protein involved in exocytosis, autophagy, and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	VAMP8
Full Name	Vesicle Associated Membrane Protein 8 (Endobrevin)
Aliases	Vesicle Associated Membrane Protein 8
Chromosome	2p12
Function	is a member of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) protein family essential for intracellular vesicle fusion events[@borre2012].
Primary Expression	Brain, Pancreas, Kidney, Heart, Liver, Lung
Amino Acids	116 aa
Exons	5
Pathways	Autophagy, Cell Cycle, Lysosomal Degradation, Mitophagy
UniProt ID	Q15886
NCBI Gene ID	9529
Ensembl ID	ENSG00000118640
OMIM	603177
GeneCards	VAMP8
Human Protein Atlas	VAMP8
Associated Diseases	ALS, Glioblastoma, Melanoma, Ms, Parkinson
Known Drugs/Compounds	rapamycin
Interactions	PI3K, STX17, TFE3, G3BP1, DRAM1, SNAP29
KG Connections	457 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VAMP8 — AlphaFold Q15886 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VAMP8["VAMP8"] -->|"Associated With"| Glioblastoma["Glioblastoma"]
    VAMP8["VAMP8"] -->|"Associated With"| Tumor["Tumor"]
    VAMP8["VAMP8"] -->|"Associated With"| Parkinson["Parkinson"]
    VAMP8["VAMP8"] -->|"Associated With"| Ms["Ms"]
    VAMP8["VAMP8"] -->|"Associated With"| Als["Als"]
    VAMP8["VAMP8"] -->|"Regulates"| Cancer["Cancer"]
    VAMP8["VAMP8"] -->|"Activates"| Carcinoma["Carcinoma"]
    VAMP8["VAMP8"] -->|"Activates"| Hepatitis["Hepatitis"]
    zinc["zinc"] -->|"Inhibits"| VAMP8["VAMP8"]
    STX17["STX17"] -->|"Interacts With"| VAMP8["VAMP8"]
    zinc_influx["zinc influx"] -->|"Inhibits"| VAMP8["VAMP8"]
    OPTN["OPTN"] -->|"Associated With"| VAMP8["VAMP8"]
    ULK1["ULK1"] -->|"Associated With"| VAMP8["VAMP8"]
    style VAMP8 fill:#8d4900,color:#e0e0e0
    style Glioblastoma fill:#b71c1c,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Carcinoma fill:#b71c1c,color:#e0e0e0
    style Hepatitis fill:#b71c1c,color:#e0e0e0
    style zinc fill:#0d47a1,color:#e0e0e0
    style STX17 fill:#0d47a1,color:#e0e0e0
    style zinc_influx fill:#607D8B,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style ULK1 fill:#8d4900,color:#e0e0e0

Outgoing (245)

Target	Relation	Type	Str
Autophagosome-Lysosome Fusion	mediates	process	0.95
Autophagosome-Lysosome Fusion	involved_in	process	0.90
autophagy pathway	participates_in	pathway	0.90
Autophagy	involved_in	process	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
Tumor	associated_with	disease	0.75
LC3	associated_with	gene	0.70
STX17	associated_with	gene	0.70
SNAP29	associated_with	gene	0.70
ULK1	associated_with	gene	0.70
LAMP1	associated_with	gene	0.70
Autophagy	activates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Autophagy	regulates	pathway	0.70
Glioblastoma	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Als	interacts_with	disease	0.65
Carcinoma	activates	disease	0.65
Ms	regulates	disease	0.65
Als	activates	disease	0.65
Hepatitis	activates	disease	0.65
Glioma	regulates	disease	0.65
Carcinoma	inhibits	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Hepatitis	regulates	disease	0.65
Cancer	inhibits	disease	0.65
ALS	associated_with	disease	0.65
Melanoma	associated_with	disease	0.65
Infection	activates	disease	0.65
Bacterial Infection	activates	disease	0.65
Inflammation	activates	disease	0.65
Melanoma	regulates	disease	0.65
Breast Cancer	regulates	disease	0.65
Pancreatic Cancer	regulates	disease	0.65
Gastric Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Infection	interacts_with	disease	0.65
Melanoma	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
LAMP2	associated_with	gene	0.60
GBM	associated_with	gene	0.60
EPG5	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60

Incoming (212)

Source	Relation	Type	Str
zinc	inhibits	protein	0.90
STX17	interacts_with	protein	0.80
zinc influx	inhibits	phenotype	0.80
CREB	regulates	gene	0.80
rapamycin	targets	drug	0.80
SQSTM1	associated_with	gene	0.70
STX17	inhibits	gene	0.70
RB1	activates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
ATG	activates	gene	0.70
MAP1LC3	activates	gene	0.70
RUBCNL	activates	gene	0.70
OPTN	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
STX17	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
RB1	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
SDC1	associated_with	gene	0.60
P62	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
TGM2	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
EP300	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
VAMP7	associated_with	gene	0.60
GABARAPL1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

VAMP8

Understanding Entity Pages

Summary

Wiki Pages (21)

VAMP8 — Vesicle Associated Membrane Protein 8

cbs-psp-daily-action-plan

Autophagy Mechanisms

Mitophagy Pathway in Neurodegeneration

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

Copper Dyshomeostasis in Neurodegeneration

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Lysosomal Dysfunction in Neurodegeneration

autophagy-lysosomal-alzheimers

zinc-homeostasis-neurodegeneration

Protein Quality Control in Neurodegeneration

Autophagy-Lysosomal Pathway

Membrane Trafficking Pathway Dysfunction in Neurodegeneration

RAB39B Endosomal-Lysosomal Dysfunction PD Causal Chain

Mitophagy

Autophagy Types in Neurodegeneration

GBA Glucocerebrosidase Endolysosomal Pathway in Parkinson's Disease

autophagy-lysosomal-ad

STX12 - Syntaxin 12