gene

GABARAPL2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABARAPL2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

127Connections

0Hypotheses

0Analyses

50Outgoing

38Incoming

Summary

GABARAPL2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Alzheimer. Connected to 97 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GABARAPL2
Chromosome	16q24.1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	various tissues:
Molecular Weight	~14 kDa
Amino Acids	117 aa
Exons	7 exons
Pathways	Autophagy
GeneCards	GABARAPL2
Human Protein Atlas	GABARAPL2
Feature	Details
Genomic Coordinates	GRCh38: Chr16: 88,547,407-88,565,432
Gene Length	~18 kb
mRNA Length	~1.2 kb
Protein Length	117 amino acids
Associated Diseases	ALS, Amyotrophic Lateral Sclerosis, Dementia, Diabetes, Frontotemporal Dementia
Interactions	SIRT5, BNIP3, PINK1, PARK2, MAP1LC3B, GABARAP
KG Connections	127 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GABARAPL2["GABARAPL2"] -->|"activates"| Cancer["Cancer"]
    GABARAPL2["GABARAPL2"] -->|"activates"| Als["Als"]
    GABARAPL2["GABARAPL2"] -->|"regulates"| Als_1["Als"]
    GABARAPL2["GABARAPL2"] -->|"regulates"| Cancer_2["Cancer"]
    GABARAPL2["GABARAPL2"] -->|"regulates"| Alzheimer["Alzheimer"]
    GABARAPL2["GABARAPL2"] -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    ATG["ATG"] -->|"activates"| GABARAPL2["GABARAPL2"]
    GABARAP["GABARAP"] -->|"activates"| GABARAPL2["GABARAPL2"]
    BNIP3["BNIP3"] -->|"activates"| GABARAPL2["GABARAPL2"]
    SIRT5["SIRT5"] -->|"activates"| GABARAPL2["GABARAPL2"]
    style GABARAPL2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (89)

Target	Relation	Type	Str
autophagosome-lysosome fusion	regulates	process	0.92
Als	associated_with	disease	0.75
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	activates	disease	0.65
Breast Cancer	activates	disease	0.65
Als	implicated_in	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
SIRT5	activates	gene	0.60
BNIP3	activates	gene	0.60
PINK1	activates	gene	0.60
PARK2	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
SIRT5	regulates	gene	0.60
P62	associated_with	gene	0.60
LC3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
FOXO3	associated_with	gene	0.60
LAMP2	expressed_in	gene	0.60
RB1CC1	expressed_in	gene	0.60
EIF2AK3	expressed_in	gene	0.60
GAPDH	associated_with	gene	0.60
HSPA5	expressed_in	gene	0.60
ITPR1	associated_with	gene	0.60
WIPI1	associated_with	gene	0.60
SNX2	expressed_in	gene	0.60
ATG10	expressed_in	gene	0.60
WIPI2	expressed_in	gene	0.60
GABARAP	activates	gene	0.60
TBK1	regulates	gene	0.60
MAP1LC3B	biomarker_for	entity	0.60
PARK2	biomarker_for	entity	0.60
PINK1	biomarker_for	entity	0.60
RAB7A	phosphorylates	gene	0.60

Incoming (38)

Source	Relation	Type	Str
SIK2	phosphorylates	gene	0.95
GABARAPL1	associated_with	gene	0.70
LC3B	associated_with	gene	0.70
ATG	activates	gene	0.70
GABARAP	activates	gene	0.60
BNIP3	activates	gene	0.60
SIRT5	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
PINK1	activates	gene	0.60
UVRAG	associated_with	gene	0.60
ULK2	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
CLN3	expressed_in	gene	0.60
PARK2	activates	gene	0.60
LC3	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
SQSTM1	regulates	gene	0.60
OPTN	associated_with	gene	0.60
RAB7A	regulates	gene	0.60
P62	regulates	gene	0.60
BNIP3	biomarker_for	entity	0.60
GABARAP	biomarker_for	entity	0.60
SQSTM1	phosphorylates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
MITOPHAGY	associated_with	gene	0.60
MITOPHAGY	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
CANCER	activates	gene	0.60
ATG8	associated_with	gene	0.60
AUTOPHAGY	implicated_in	gene	0.60
ENDOSOME	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
ALS	associated_with	gene	0.60
MITOCHONDRIA	activates	gene	0.60
BNIP3	co_expressed_with	gene	0.50
GABARAP	co_expressed_with	protein	0.50
Autophagy	activates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GABARAPL2

Understanding Entity Pages

Summary

Wiki Pages (21)

GABARAPL2 Gene

CBS Autophagy-Lysosomal Pathway Dysfunction

ATG4D Gene

ATG4B — Autophagy Related 4B Cysteine Peptidase

GABARAP Protein

ATG4C Gene

snx2

ATG4B Protein — Autophagy Related 4B

STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease

Phosphoproteomics in Neurodegeneration

ATG4A Protein

ULK2 Gene

GABARAPL2 Protein

BECN2 Protein

FAM134B — Family With Sequence Similarity 134 Member B

MAP1LC3A Gene

GABARAPL1 — GABA Type A Receptor Associated Protein Like 1

ATG4A Gene

GAIN Protein (GABARAPL2) - GABA-A Receptor Associated Protein Like 2