gene

TRKB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRKB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

938Connections

3Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

TRKB is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 362 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TRKB
Chromosome	9q21.33
Protein Type	Receptor
Function	is a high-affinity receptor tyrosine kinase that serves as the primary signaling receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4).
Subcellular Localization	</th><td>Cell membrane, endosomes, nucleus, mitochondria</td></tr>
Molecular Weight	140 kDa
Amino Acids	796 aa
Exons	24
Pathways	Akt, Apoptosis, Cell Cycle, Long-Term Potentiation, Mapk
UniProt ID	Q16620
NCBI Gene ID	4915
Ensembl ID	ENSG00000148053
GeneCards	TRKB
Human Protein Atlas	TRKB
Associated Diseases	Aging, Als, Alzheimer, Alzheimer'S Disease, Cancer
Interactions	ACHE, Actin, ADAM10, AEP, AGING, AKT
KG Connections	917 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TRKB — AlphaFold Q16620 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TrkB Protein

protein · 2434 words

→

TRKB Gene

gene · 1383 words

→

Pathway Diagram

flowchart TD
    BDNF["BDNF
Brain-Derived
Neurotrophic Factor"]
    TRKB["TRKB
Tropomyosin Receptor
Kinase B"]
    FGF7["FGF7
Fibroblast Growth
Factor 7"]
    
    Neurodegeneration["Neurodegeneration
General Process"]
    Alzheimer["Alzheimer's
Disease"]
    Parkinson["Parkinson's
Disease"]
    ALS["Amyotrophic Lateral
Sclerosis (ALS)"]
    MS["Multiple
Sclerosis"]
    
    Depression["Depression
Mood Disorder"]
    Stroke["Stroke
Cerebrovascular
Event"]
    Ischemia["Ischemia
Reduced Blood
Flow"]
    Aging["Aging
Process"]
    
    Inflammation["Inflammation
Immune Response"]
    Fibrosis["Fibrosis
Tissue Scarring"]
    
    NeuroprotectiveEffects["Neuroprotective
Effects"]
    TissueRepair["Tissue Repair
 and Regeneration"]

    BDNF -->|"activates"| TRKB
    TRKB -->|"regulates"| FGF7
    TRKB -->|"promotes"| NeuroprotectiveEffects
    TRKB -->|"enhances"| TissueRepair
    
    TRKB -->|"therapeutic_target"| Neurodegeneration
    TRKB -->|"therapeutic_target"| Alzheimer
    TRKB -->|"therapeutic_target"| Parkinson
    TRKB -->|"therapeutic_target"| ALS
    TRKB -->|"therapeutic_target"| MS
    TRKB -->|"therapeutic_target"| Depression
    
    TRKB -->|"inhibits"| Aging
    TRKB -->|"inhibits"| Fibrosis
    TRKB -->|"regulates"| Inflammation
    
    Ischemia -->|"leads_to"| Stroke
    Aging -->|"contributes_to"| Neurodegeneration

    style TRKB fill:#006494
    style BDNF fill:#1b5e20
    style NeuroprotectiveEffects fill:#1b5e20
    style TissueRepair fill:#1b5e20
    style FGF7 fill:#4a1a6b
    style Neurodegeneration fill:#ef5350
    style Alzheimer fill:#ef5350
    style Parkinson fill:#ef5350
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Aging fill:#5d4400
    style Depression fill:#5d4400
    style Stroke fill:#5d4400
    style Inflammation fill:#ef5350
    style Fibrosis fill:#ef5350

Outgoing (607)

Target	Relation	Type	Str
TRKB	encodes	protein	0.00
Als	activates	disease	1.00
BDNF	activates	gene	1.00
Synaptic Plasticity	activates	pathway	1.00
Inflammation	activates	disease	0.95
Aging	activates	disease	0.95
Depression	activates	disease	0.95
BDNF signaling	activates	pathway	0.92
PLC/IP3 pathway	activates	pathway	0.90
PI3K	interacts_with	protein	0.90
Neurotrophic Signaling	involved_in	pathway	0.90
PI3K	interacts_with	gene	0.90
AKT	activates	gene	0.90
DEPRESSION	activates	gene	0.90
ERK	activates	protein	0.88
Depression	therapeutic_target	disease	0.85
Als	regulates	disease	0.85
CREB	phosphorylates	protein	0.85
Als	associated_with	disease	0.85
Neurodegeneration	activates	disease	0.85
synaptic protein expression	regulates	process	0.80
BDNF	therapeutic_target	gene	0.80
TNF-Α	activates	gene	0.80
DEPRESSION	therapeutic_target	gene	0.80
AGING	activates	gene	0.80
P75NTR	activates	gene	0.80
Neurogenesis	activates	pathway	0.80
Neuroinflammation	activates	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Alzheimer	therapeutic_target	disease	0.75
Als	inhibits	disease	0.75
Ischemia	activates	disease	0.75
Stroke	activates	disease	0.75
Diabetes	activates	disease	0.75
JAK	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
acute lung injury	treats	disease	0.70
NEUROINFLAMMATION	activates	gene	0.70
Apoptosis	activates	pathway	0.70
Differentiation	activates	pathway	0.70
Microbiota	activates	pathway	0.70
FGF7	regulates	protein	0.70
Pi3K/Akt	activates	pathway	0.70
Oxidative Stress	activates	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Apoptosis	regulates	pathway	0.70
BDNF	causes	gene	0.70
Oxidative Stress	regulates	pathway	0.70
EXERCISE	activates	gene	0.70

Incoming (331)

Source	Relation	Type	Str
TRKB	encodes	gene	0.00
BDNF	activates	protein	1.00
BDNF	associated_with	gene	1.00
LSD	binds_to	drug	0.95
psilocin	binds_to	drug	0.95
BDNF	binds_to	protein	0.95
Exercise Training	upregulates	process	0.93
BDNF	expresses	gene	0.90
AMYLOID BETA	degrades	protein	0.90
BDNF	activates	protein	0.90
BDNF	encodes_ligand_for	gene	0.90
TNF	activates	gene	0.90
BDNF	binds	gene	0.80
ABETA	inhibits	protein	0.80
NEURODEGENERATION	activates	gene	0.80
PI3K	activates	gene	0.80
BDNF	interacts_with	protein	0.72
ANA-12	inhibits	drug	0.70
BDNF	regulates	gene	0.70
7,8-DHF	activates	drug	0.70
BDNF	interacts_with	protein	0.70
TAU	therapeutic_target	gene	0.70
EPILEPSY	associated_with	gene	0.70
HUNTINGTON	associated_with	gene	0.70
EXERCISE	activates	gene	0.70
STROKE	activates	gene	0.70
IL-6	activates	gene	0.70
ERK	activates	gene	0.70
DEPRESSION	associated_with	gene	0.70
NRD-143	activates	drug	0.70
DCX	activates	gene	0.60
NESTIN	activates	gene	0.60
BAX	expressed_in	gene	0.60
NTRK2	activates	gene	0.60
TAU	protects_against	gene	0.60
BDNF	therapeutic_target	gene	0.60
BDNF	protects_against	gene	0.60
RB1	therapeutic_target	gene	0.60
GAN	inhibits	gene	0.60
TLR3	contributes_to	gene	0.60
EGFR	activates	gene	0.60
AKT	regulates	gene	0.60
SYN3	activates	gene	0.60
TNF	biomarker_for	gene	0.60
NLRP3	biomarker_for	gene	0.60
NPTXR	activates	gene	0.60
SIRT1	regulates	gene	0.60
PI3K	regulates	gene	0.60
FOXP3	activates	gene	0.60
LRP8	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Activity-Dependent Synaptic Tagging via CREB-BDNF-TrkB Signa	0.646	synaptic-biology	What determines the selectivity of compl
5-HT2A/C Silencing Enables Sustained BDNF-TrkB Signaling for	0.545	-	What is the minimum effective dose of tr
HBOT at 2.0 ATA for 60 min, 5x/week for 6 weeks enhances hip	0.450	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (2)

Scientific analyses that reference this entity

What genetic risk factors predispose individuals to developing CTE following rep

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.552

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.756

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning TRKB in their description or question text

No additional research found