gene

MFSD2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MFSD2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections

2Hypotheses

0Analyses

38Outgoing

16Incoming

Summary

Page for MFSD2A - Major Facilitator Superfamily Domain Containing 2A

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🧬 Gene Info

Gene Symbol	MFSD2A
Full Name	Major Facilitator Superfamily Domain Containing 2A
Aliases	Page for MFSD2A
Chromosome	1p34.2
Protein Type	Transporter
Function	encodes a sodium-dependent lysophosphatidylcholine (LPC) transporter that is essential for blood-brain barrier integrity and brain lipid composition.
Amino Acids	530 aa
Exons	14
Pathways	Blood-Brain Barrier
Ensembl ID	ENSG00000168389
GeneCards	MFSD2A
Human Protein Atlas	MFSD2A
Associated Diseases	neurodegeneration
Interactions	PDGFRB, CANCER, NF-ΚB, NEUROINFLAMMATION, PROINFLAMMATORY CYTOKINES, CAVEOLIN-1
KG Connections	54 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MFSD2A["<b>MFSD2A</b>"]
    Ischemia{"Ischemia"}
    MFSD2A -->|"regulates"| Ischemia
    Stroke{"Stroke"}
    MFSD2A -->|"activates"| Stroke
    Ms{"Ms"}
    MFSD2A -->|"activates"| Ms
    Blood_Brain_Barrier(["Blood-Brain Barrier"])
    MFSD2A -->|"regulates"| Blood_Brain_Barrier
    neurodegeneration["neurodegeneration"]
    MFSD2A -->|"implicated in"| neurodegeneration
    TAZ["TAZ"]
    TAZ -->|"regulates"| MFSD2A
    style MFSD2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (38)

Target	Relation	Type	Str
PDGFRB	inhibits	gene	0.65
Ischemia	regulates	disease	0.65
Stroke	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	inhibits	disease	0.65
Colorectal Cancer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Gastric Cancer	inhibits	disease	0.65
Sepsis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
MICROGLIA	regulates	cell_type	0.65
OLIGODENDROCYTE	causes	cell_type	0.65
BLOOD-BRAIN BARRIER DISRUPTION	inhibits	phenotype	0.65
HYPOTHALAMUS	activates	brain_region	0.65
STROKE	targets	disease	0.65
STROKE	biomarker_for	disease	0.65
NEURON	interacts_with	cell_type	0.65
Blood-Brain Barrier	regulates	pathway	0.60
CANCER	inhibits	gene	0.60
Metastasis	inhibits	pathway	0.60
Invasion	inhibits	pathway	0.60
Angiogenesis	inhibits	pathway	0.60
NF-ΚB	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
PROINFLAMMATORY CYTOKINES	activates	gene	0.60
Wnt	inhibits	pathway	0.60
Blood-Brain Barrier	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
AND	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
Albumin	expressed_in	protein	0.60
OLIGODENDROCYTE	expressed_in	cell_type	0.55
CAVEOLIN-1	activates	protein	0.50

Incoming (16)

Source	Relation	Type	Str
h-f5d32997	targets_gene	hypothesis	0.90
ENDOTHELIAL CELLS	regulates	cell_type	0.65
NEURONS	produces	cell_type	0.65
TAZ	regulates	gene	0.60
STAT3	inhibits	gene	0.60
WNT7A	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
AND	inhibits	gene	0.60
CYTOKINES	activates	gene	0.60
MICROGLIA	activates	gene	0.60
WNT	inhibits	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
HIPPOCAMPUS	associated_with	brain_region	0.45
CEREBELLUM	associated_with	brain_region	0.45
HYPOTHALAMUS	associated_with	brain_region	0.45

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
MFSD2A-Targeted Lysophosphatidylcholine-SPM Conjugates as CN	0.552	neuropharmacology	What determines blood-brain barrier pene
SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression R	0.498	neuropharmacology	What determines blood-brain barrier pene

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MFSD2A

Understanding Entity Pages

Summary

Wiki Pages (8)

MFSD2A - Major Facilitator Superfamily Domain Containing 2A

omega-3-fatty-acids-neurodegeneration

blood-brain-barrier

Glymphatic System Dysfunction Pathway

omega-3-fatty-acids-parkinsons

ALA-enriched Nutrition for APOE4 Carriers with MCI (NCT07392723)