concept

TBI

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TBI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

133Connections

0Hypotheses

1Analyses

36Outgoing

50Incoming

Summary

TBI is a concept in neurodegeneration research. Key relationships include: co discussed, associated with, inhibits. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 74 entities in the SciDEX knowledge graph.

View on Wiki →

💡 Concept Info

Name	TBI
Key Genes/Proteins	NF-KB, AKT
Related Diseases	ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, ALS, TRAUMATIC BRAIN INJURY
Related Pathways	NEUROPROTEOMICS, autophagy

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TBI["<b>TBI</b>"]
    TBI -->|"regulates"| BRAIN["BRAIN"]
    TBI -->|"causes"| neuroinflammation["neuroinflammation"]
    TBI -->|"inhibits"| autophagy["autophagy"]
    TBI -->|"causes"| neuroinflammatory_responses["neuroinflammatory responses"]
    NEUROPROTEOMICS["NEUROPROTEOMICS"] -->|"investigates"| TBI
    AGING["AGING"] -->|"causes"| TBI
    NEURON["NEURON"] -->|"interacts"| TBI
    INFLAMMATION["INFLAMMATION"] -->|"regulates"| TBI
    MICROGLIA["MICROGLIA"] -->|"regulates"| TBI
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"regulates"| TBI
    RIPK1["RIPK1"] -->|"treats"| TBI
    RIPK3["RIPK3"] -->|"treats"| TBI
    APOPTOSIS["APOPTOSIS"] -->|"causes"| TBI

Outgoing (36)

Target	Relation	Type	Str
BRAIN	regulates	brain_region	0.72
neuroinflammation	causes	process	0.70
autophagy	inhibits	pathway	0.70
neuroinflammatory responses	causes	process	0.70
TRAUMATIC BRAIN INJURY	interacts_with	disease	0.65
TRAUMATIC BRAIN INJURY	contributes_to	disease	0.65
TRAUMATIC BRAIN INJURY	causes	disease	0.65
TRAUMATIC BRAIN INJURY	promotes	disease	0.65
TRAUMATIC BRAIN INJURY	impairs	disease	0.65
TNF	activates	gene	0.60
TUMOR	activates	disease	0.60
TH	activates	gene	0.60
TLR4	mediates	gene	0.60
TREM2	activates	gene	0.60
WHITE MATTER	contributes_to	brain_region	0.60
TNF	co_discussed	entity	0.50
WHITE MATTER	co_discussed	entity	0.50
APOPTOSIS	inhibits	process	0.50
NEUROINFLAMMATION	regulates	process	0.50
NEURODEGENERATION	associated_with	process	0.50
NEUROINFLAMMATION	associated_with	process	0.50
APOPTOSIS	associated_with	process	0.50
FERROPTOSIS	associated_with	process	0.50
NECROPTOSIS	associated_with	process	0.50
PYROPTOSIS	associated_with	process	0.50
NEUROINFLAMMATION	activates	process	0.50
PYROPTOSIS	activates	process	0.50
OXIDATIVE STRESS	regulates	process	0.50
OXIDATIVE STRESS	inhibits	process	0.50
NEURODEGENERATION	causes	process	0.50
REMYELINATION	involved_in	process	0.50
AGING	activates	process	0.50
DEPRESSION	regulates	disease	0.50
APOPTOSIS	activates	process	0.50
TUMOR	co_discussed	disease	0.40
TREM2	co_discussed	gene	0.40

Incoming (97)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
MICROGLIA	associated_with	cell_type	0.90
PARKINSON'S DISEASE	associated_with	disease	0.90
ASTROCYTES	associated_with	cell_type	0.74
ALS	associated_with	disease	0.74
NF-KB	associated_with	protein	0.74
NEUROPROTEOMICS	investigates	pathway	0.72
AKT	associated_with	gene	0.66
MICROGLIA	activates	cell_type	0.66
NEURON	reduces	cell_type	0.65
ANXIETY	associated_with	disease	0.65
NEURON	expressed_in	cell_type	0.65
HMGB1	expressed_in	gene	0.65
NEURON	interacts_with	cell_type	0.60
DEPRESSION	associated_with	disease	0.60
ALZHEIMER	associated_with	disease	0.60
ALZHEIMER'S	associated_with	disease	0.60
RIPK1	treats	gene	0.60
RIPK3	treats	gene	0.60
NEURON	causes	cell_type	0.60
NEURON	regulates	cell_type	0.60
MICROGLIA	mediates	cell_type	0.60
NEURON	inhibits	cell_type	0.60
NEURONS	inhibits	cell_type	0.60
MICROGLIA	protects_against	cell_type	0.60
T CELL	protects_against	cell_type	0.60
MICROGLIA	promotes	cell_type	0.60
NEURON	protects_against	cell_type	0.60
ASTROCYTE	interacts_with	cell_type	0.60
ASTROCYTES	interacts_with	cell_type	0.60
CORTEX	interacts_with	brain_region	0.60
NEURONS	interacts_with	cell_type	0.60
NEURON	exacerbates	cell_type	0.60
NLRP3	mediates	gene	0.60
NEUTROPHIL	mediates	cell_type	0.60
NEUTROPHIL	associated_with	cell_type	0.60
NEUTROPHIL	causes	cell_type	0.60
NEURONS	protects_against	cell_type	0.60
MICROGLIA	regulates	cell_type	0.58
NEURODEGENERATION	causes	disease	0.58
MTOR	associated_with	gene	0.56
T CELL	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50
NEURON	co_discussed	entity	0.50
APOPTOSIS	co_discussed	entity	0.50
CYTOKINE	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50
DEPRESSION	co_discussed	entity	0.50
ALZHEIMER'S	co_discussed	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why do p300/CBP inhibitors reduce both AD incidence and clinically diagnosed TBI

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.604

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TBI

Understanding Entity Pages

Summary

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

Corticobasal Degeneration (CBD)

Multiple System Atrophy

TREM2 Mechanism Hub

rasagiline

Synucleinopathy Mechanism

Tau Spreading Mechanism

Traumatic Brain Injury and Neurodegeneration Pathway

Excitotoxicity in Neurodegeneration

Neuroprotection Strategies in Neurodegeneration

NPAS3 Gene

creatine-supplementation-neurodegeneration

Experiment Prioritization Index — Neurodegeneration

neurovascular-coupling

DNA Damage Response Impairment Pathway

Notch Signaling Pathway in Neurodegeneration

NF-kB Signaling Pathway in Neurodegeneration

Frontotemporal Dementia

Creatine for Neuroprotection