Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about WNT11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Wnt Family Member 11 - secreted signaling protein primarily activating non-canonical Wnt/PCP and Wnt/Calcium pathways, regulating cell polarity and neuronal development
| Gene Symbol | WNT11 |
| Aliases | Wnt Family Member 11 |
| Function | Like all Wnt proteins, WNT11 contains several structural features essential for its function |
| Amino Acids | 354 aa |
| Pathways | WNT, Wnt, Wnt signaling, Wnt pathway |
| Ensembl ID | ENSG00000169718 |
| GeneCards | WNT11 |
| Human Protein Atlas | WNT11 |
| Wnt domain (residues 51-354) | The conserved signaling domain containing multiple cysteine residues |
| Conserved cysteine pattern | Ten conserved cysteine residues form disulfide bonds that stabilize the protein structure |
| Lipid modification site | Palmitoylation at a conserved cysteine is required for proper secretion and activity |
| Convergent extension | Cell movements during gastrulation and neural tube closure |
| Tissue patterning | Establishing planar polarity in epithelial tissues |
| Axonal guidance | Directional growth of axons during development |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | GRIN3B, TNFRSF1B, TNFRSF13C, HCRTR1, MYO7A, CHRM4 |
| KG Connections | 41 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
WNT11["WNT11"]
Als["Als"]
GRIN3B["GRIN3B"]
TNFRSF1B["TNFRSF1B"]
GABA["GABA"]
TNFRSF13C["TNFRSF13C"]
HCRTR1["HCRTR1"]
CYTOKINES["CYTOKINES"]
Wnt["Wnt"]
Microglia["Microglia"]
Astrocyte["Astrocyte"]
CHRM4["CHRM4"]
MYO7A["MYO7A"]
GRM2["GRM2"]
WNT1["WNT1"]
ASTROCYTE["ASTROCYTE"]
CRH["CRH"]
WNT["WNT"]
ADRA2B["ADRA2B"]
IL13["IL13"]
CHRNE["CHRNE"]
WNT11 -->|"activates"| Als
WNT11 -->|"activates"| GRIN3B
WNT11 -->|"activates"| TNFRSF1B
WNT11 -->|"activates"| GABA
WNT11 -->|"activates"| TNFRSF13C
WNT11 -->|"activates"| HCRTR1
WNT11 -->|"activates"| CYTOKINES
WNT11 -->|"activates"| Wnt
WNT11 -->|"activates"| Microglia
WNT11 -->|"activates"| Astrocyte
CHRM4 -->|"activates"| WNT11
MYO7A -->|"activates"| WNT11
GRM2 -->|"activates"| WNT11
WNT1 -->|"activates"| WNT11
ASTROCYTE -->|"activates"| WNT11
CRH -->|"activates"| WNT11
WNT -->|"activates"| WNT11
ADRA2B -->|"activates"| WNT11
IL13 -->|"activates"| WNT11
CHRNE -->|"activates"| WNT11
style WNT11 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| GRIN3B | activates | gene | 0.60 |
| TNFRSF1B | activates | gene | 0.60 |
| TNFRSF13C | activates | gene | 0.60 |
| HCRTR1 | activates | gene | 0.60 |
| MYO7A | activates | gene | 0.60 |
| CHRM4 | activates | gene | 0.60 |
| ADRA2B | activates | gene | 0.60 |
| IL13 | activates | gene | 0.60 |
| CHRNE | activates | gene | 0.60 |
| GRM2 | activates | gene | 0.60 |
| CRH | activates | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| GABA | activates | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| Wnt | activates | pathway | 0.60 |
| Microglia | activates | cell_type | 0.60 |
| Astrocyte | activates | cell_type | 0.60 |
| AND | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| ASTROCYTE | activates | gene | 0.60 |
| Brainstem | expressed_in | brain_region | 0.55 |
| Astrocyte | expressed_in | cell_type | 0.55 |
| Microglia | expressed_in | cell_type | 0.55 |
| WNT1 | activates | gene | 0.50 |
| WNT SIGNALING | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CHRM4 | activates | gene | 0.60 |
| MYO7A | activates | gene | 0.60 |
| GRM2 | activates | gene | 0.60 |
| WNT1 | activates | gene | 0.60 |
| CRH | activates | gene | 0.60 |
| ADRA2B | activates | gene | 0.60 |
| IL13 | activates | gene | 0.60 |
| CHRNE | activates | gene | 0.60 |
| TNFRSF1B | activates | gene | 0.60 |
| GRIN3B | activates | gene | 0.60 |
| HCRTR1 | activates | gene | 0.60 |
| ASTROCYTE | activates | gene | 0.60 |
| WNT | activates | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||