gene

TNFRSF13C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFRSF13C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

0Analyses

42Outgoing

24Incoming

Summary

BAFFR Gene (TNFRSF13C)

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🧬 Gene Info

Gene Symbol	TNFRSF13C
Full Name	TNF Receptor Superfamily Member 13C
Chromosome	22q12.1
Protein Family	TNF receptor superfamily
Protein Type	Receptor
Function	is a critical member of the TNF receptor superfamily that plays an essential and non-redundant role in B cell survival, maturation, and homeostasis.
Exons	5
Pathways	Wnt
UniProt ID	Q9Y239
NCBI Gene ID	115650
Ensembl ID	ENSG00000159958
OMIM	606269
GeneCards	TNFRSF13C
Human Protein Atlas	TNFRSF13C
Alternative Names	BAFFR, BR3, CD268
Associated Diseases	Ataxia, Neurodegeneration, Spinocerebellar Ataxia, disease
Interactions	HCRTR1, CHRM4, MYO7A, ADRA2B, GRM2, CRH
KG Connections	66 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TNFRSF13C — AlphaFold Q9Y239 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TNFRSF13C["TNFRSF13C"]
    Sj_gren_s_Syndrome["Sjögren's Syndrome"]
    Als["Als"]
    Neurodegeneration["Neurodegeneration"]
    HCRTR1["HCRTR1"]
    CYTOKINES["CYTOKINES"]
    Wnt["Wnt"]
    Microglia["Microglia"]
    Astrocyte["Astrocyte"]
    SCA3["SCA3"]
    Oligodendrocyte["Oligodendrocyte"]
    Neuron["Neuron"]
    CHRM4["CHRM4"]
    MYO7A["MYO7A"]
    GRM2["GRM2"]
    WNT1["WNT1"]
    ASTROCYTE["ASTROCYTE"]
    CRH["CRH"]
    WNT["WNT"]
    ADRA2B["ADRA2B"]
    IL13["IL13"]
    TNFRSF13C -->|"involved in"| Sj_gren_s_Syndrome
    TNFRSF13C -->|"activates"| Als
    TNFRSF13C -.-|"associated"| Neurodegeneration
    TNFRSF13C -->|"activates"| HCRTR1
    TNFRSF13C -->|"activates"| CYTOKINES
    TNFRSF13C -->|"activates"| Wnt
    TNFRSF13C -->|"activates"| Microglia
    TNFRSF13C -->|"activates"| Astrocyte
    TNFRSF13C -.-|"associated"| SCA3
    TNFRSF13C -.-|"associated"| Oligodendrocyte
    TNFRSF13C -.-|"associated"| Neuron
    CHRM4 -->|"activates"| TNFRSF13C
    MYO7A -->|"activates"| TNFRSF13C
    GRM2 -->|"activates"| TNFRSF13C
    WNT1 -->|"activates"| TNFRSF13C
    ASTROCYTE -->|"activates"| TNFRSF13C
    CRH -->|"activates"| TNFRSF13C
    WNT -->|"activates"| TNFRSF13C
    ADRA2B -->|"activates"| TNFRSF13C
    IL13 -->|"activates"| TNFRSF13C
    style TNFRSF13C fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (42)

Target	Relation	Type	Str
Als	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
ALS	activates	disease	0.65
Ataxia	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65
Neurodegeneration	stabilizes	disease	0.65
HCRTR1	activates	gene	0.60
SCA3	associated_with	gene	0.60
ATXN3	associated_with	gene	0.60
CHRM4	activates	gene	0.60
MYO7A	activates	gene	0.60
ADRA2B	activates	gene	0.60
GRM2	activates	gene	0.60
SCA3	encodes	gene	0.60
CRH	activates	gene	0.60
CHRNE	activates	gene	0.60
GRIN3B	activates	gene	0.60
TNFRSF1B	activates	gene	0.60
WNT1	activates	gene	0.60
Rb	activates	protein	0.60
Rb	associated_with	protein	0.60
CYTOKINES	activates	gene	0.60
Wnt	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
Oligodendrocyte	associated_with	cell_type	0.60
Neuron	associated_with	cell_type	0.60
GABA	activates	gene	0.60
AND	associated_with	gene	0.60
Cytokine	activates	protein	0.60
Oligodendrocyte	encodes	cell_type	0.60
Neuron	stabilizes	cell_type	0.60
Brainstem	expressed_in	brain_region	0.55
Ca3	expressed_in	brain_region	0.55
Astrocyte	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
White Matter	expressed_in	brain_region	0.55
Oligodendrocyte	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
CYTOKINE	activates	concept	0.50
disease	associated_with	disease	0.50
BRAINSTEM	associated_with	concept	0.50

Incoming (24)

Source	Relation	Type	Str
CHRM4	activates	gene	0.60
MYO7A	activates	gene	0.60
GRM2	activates	gene	0.60
WNT1	activates	gene	0.60
CRH	activates	gene	0.60
ADRA2B	activates	gene	0.60
IL13	activates	gene	0.60
CHRNE	activates	gene	0.60
WNT11	activates	gene	0.60
GRIN3B	activates	gene	0.60
TNFRSF1B	activates	gene	0.60
ATXN3	associated_with	gene	0.60
HCRTR1	activates	gene	0.60
GAIN	associated_with	gene	0.60
ATXN3	stabilizes	gene	0.60
ASTROCYTE	activates	gene	0.60
WNT	activates	gene	0.60
GABA	activates	gene	0.60
CYTOKINES	activates	gene	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
OLIGODENDROCYTE	associated_with	gene	0.60
sca3	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TNFRSF13C

Understanding Entity Pages

Summary

Wiki Pages (9)

BAFFR Gene (TNFRSF13C)

TACI Gene (TNFRSF13B)

WNT11 Gene

WNT1 Gene

BAFFR (B Cell Activating Factor Receptor) Protein

TNFRSF1B Gene

CHRNE Gene